TARDBP 抗体 (N-Term)
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Quick Overview for TARDBP 抗体 (N-Term) (ABIN317572)
抗原
See all TARDBP 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-260, N-Term
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特异性
- The antibody recognizes Human TARDBP. Other species not tested.
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产品特性
- Synonyms: TDP43, TDP-43, TAR DNA-binding protein 43
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纯化方法
- Protein-G Affinity Chromatography
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免疫原
- Recombinant Human TARDBP (1-260 aa) purified from E. coli.
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亚型
- IgG1
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应用备注
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ELISA. Western blot (1/1,000-1/2,000). Immunohistochemistry on Paraffin Sections (1/50-1/100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.0 mg/mL
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缓冲液
- PBS, pH 7.4, 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. -
有效期
- 12 months
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- TARDBP (TAR DNA Binding Protein (TARDBP))
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别名
- TARDBP
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背景
- TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein. TARDBP was identified as the disease accumulating protein in patients with frontotemporal lobar degeneration (FTLD) with ubiquitin inclusions (FTLD-U) and in amyotrophic lateral sclerosis (ALS). TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. In addition, this protein regulates alternate splicing of the cystic fibrosis transmembrane receptor (CFTR) gene.Synonyms: TAR DNA-binding protein 43, TDP-43, TDP43
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基因ID
- 23435
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UniProt
- Q13148
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途径
- Positive Regulation of Peptide Hormone Secretion
抗原
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