Cytochrome C 抗体 (full length)
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北京 101111
Quick Overview for Cytochrome C 抗体 (full length) (ABIN306559)
抗原
See all Cytochrome C (CYCS) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- full length
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原理
- Sheep anti Human Cytochrome c
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交叉反应
- 人
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产品特性
- Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.
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纯化方法
- Ammonium Sulfate Precipitation
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免疫原
- Full length recombinant Cytochrome C
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亚型
- IgG
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anti-Cytochrome C, Somatic (CYCS) (AA 51-105) antibody
CYCS 适用: 人, 大鼠, 小鼠, 兔, 小鸡 WB, FACS, ELISA, IHC (p), ICC, IF (p), IHC (fro), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome C, Somatic (CYCS) (AA 1-105) antibodyCYCS 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome C, Somatic (CYCS) (AA 2-105) antibodyCYCS 适用: 人, 大鼠, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome C, Somatic (CYCS) (AA 5-100) antibodyCYCS 适用: 人 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Cytochrome C, Somatic (CYCS) (AA 13-99) antibodyCYCS 适用: 人, 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome C, Somatic (CYCS) (AA 5-100) antibodyCYCS 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome C, Somatic (CYCS) (AA 1-105) antibodyCYCS 适用: 人, 小鼠 WB, IHC, FACS, ELISA 宿主: 小鼠 Monoclonal 5E6B11 unconjugated
anti-Cytochrome C, Somatic (CYCS) antibodyCYCS 适用: 人, 大鼠, 小鼠, 小鸡 WB, IHC, IF 宿主: 小鼠 Monoclonal unconjugated
anti-Cytochrome C, Somatic (CYCS) (AA 1268-1341) antibodyCYCS 适用: 人, 大鼠, 小鼠 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome C, Somatic (CYCS) (AA 91-105), (C-Term) antibodyCYCS 适用: 人, 大鼠, 小鼠 WB, IHC, FACS, IF, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Applications: Western Blot 1:5,000, shows a MW of 14.4 kDa. May be used in immunofluorescence applications with human and rat cells, Immunoprecipitation - Empirical.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- phosphate buffered saline with 0.08 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- Cytochrome C (CYCS) (Cytochrome C, Somatic (CYCS))
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别名
- Cytochrome c
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背景
- Sheep anti cytochrome c, cyto c, cytochrome-c
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UniProt
- P99999, P62898, P00008, P00011
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途径
- Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
抗原
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