BCL2L1 抗体 (AA 3-14)
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北京 101111
Quick Overview for BCL2L1 抗体 (AA 3-14) (ABIN306551)
抗原
See all BCL2L1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 3-14
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原理
- Sheep anti Human bcl-xl
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交叉反应
- 犬, 人, 小鼠, 大鼠
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产品特性
- bcl-x is a bcl-2-related gene that can function as a regulator of programmed cell death (apoptosis) independent of bcl-2. Alternative splicing results in two distinct bcl-x mRNAs. The larger mRNA gives rise to a protein product, bcl-xl, which is similar in size and predicted structure to bcl-2 (1). The smaller mRNA gives rise to bcl-xS. bcl-x immunoreactivity has been detected in a wide variety of cell types and the protein is typically present in the cytosol in association with the mitochondrial periphery, a property shared with bcl-2 however membrane bound forms of bcl-x have been demonstrated in thymocytes (2-4). Following the induction of apoptosis all of the bcl-x protein shifts to the membrane form (2). Of the two isoforms of bcl-x, the long (bcl-xl) is the most abundant mRNA species expressed in embryonic and adult tissues and most likely differs from bcl-2 in its regulatory activity on cell differentiation through controlled tissue specific expression (1,3). Like its homolog bcl-2, bcl-x undergoes phosphorylation, a modification that requires that a specific 60 amino acid loop region be intact, which in turn appears to regulate activity (5,6). Structurally, based on 3D-structure analysis, bcl-x forms pH sensitive cation-selective ion channels in membranes a property shared with the pore forming domains of several bacterial toxins (7). Bcl-xl has been shown to modify the cell79s response to oxidants, to participate in resistance to chemotherapeutic agents and radiation, and to play a key role in the development of the developing CNS (8-10).
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纯化方法
- Ammonium Sulfate Precipitation
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免疫原
- A synthetic peptide corresponding to amino acids 3 to 14 of the human bcl-xl sequence
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亚型
- IgG
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anti-BCL2-Like 1 (BCL2L1) antibody
BCL2L1 适用: 人 WB, IF, IP, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Like 1 (BCL2L1) (AA 1-120) antibodyBCL2L1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Like 1 (BCL2L1) (AA 1-233) antibodyBCL2L1 适用: 人 WB, IF, ELISA, PLA 宿主: 小鼠 Monoclonal 3E2-2A5 unconjugated
anti-BCL2-Like 1 (BCL2L1) (AA 2-212) antibodyBCL2L1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Like 1 (BCL2L1) (AA 2-212) antibodyBCL2L1 适用: 人 WB, IHC, FACS, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Like 1 (BCL2L1) (AA 2-212) antibodyBCL2L1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C4 unconjugated
anti-BCL2-Like 1 (BCL2L1) (AA 1-233) antibodyBCL2L1 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Like 1 (BCL2L1) (AA 1-219) antibodyBCL2L1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Like 1 (BCL2L1) (AA 81-200) antibodyBCL2L1 适用: 人, 小鼠, 大鼠, Pig, 绵羊 WB, ELISA, FACS, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Like 1 (BCL2L1) (AA 1-209) antibodyBCL2L1 适用: 人 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Application: Western Blot at 1-5 μg/mL. Positive control MCF-7 cells.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- phosphate buffered saline with 0.08 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- BCL2L1 (BCL2-Like 1 (BCL2L1))
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别名
- bcl-xl
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背景
- Hbcl-xl, sheep anti human bcl-xl, bclxl, bcl xl, bclx, bcl2L1, BCL2L
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UniProt
- Q07817
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途径
- Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
抗原
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