TARDBP 抗体 (AA 1-260)
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北京 101111
Quick Overview for TARDBP 抗体 (AA 1-260) (ABIN306465)
抗原
See all TARDBP 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-260
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原理
- Human TDP-43/TARDBP antibody
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纯化方法
- Purified
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免疫原
- Recombinant human TARDBP (1-260aa) purified from E. coli
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亚型
- IgG1 kappa
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应用备注
- Recommended dilution 1:1000(W.B), Recommended dilution 1:100(IHC)
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % glycerol
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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- TARDBP (TAR DNA Binding Protein (TARDBP))
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别名
- TDP-43/TARDBP
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背景
- TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein. TARDBP was identified as the disease accumulating protein in patients with frontotemporal lobar degeneration (FTLD) with ubiquitin inclusions (FTLD-U) and in amyotrophic lateral sclerosis (ALS). TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. In addition, this protein regulates alternate splicing of the cystic fibrosis transmembrane receptor (CFTR) gene.
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NCBI登录号
- NP_031401
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途径
- Positive Regulation of Peptide Hormone Secretion
抗原
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