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VEGFA 抗体 (N-Term)

Name: VEGFA 抗体 (N-Term)
SKU: ABIN3044494
Availability: OutOfStock

VEGFA 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

Anti-VEGF antibody, Western blotting Lane 1: Recombinant Human VEGF Protein 10ng Lane 2: Recombinant Human VEGF Protein 5ng Lane 3: Recombinant Human VEGF Protein 2. (VEGFA 抗体 (N-Term))

Anti-VEGF antibody, IHC(P) IHC(P): Human Lung Cancer Tissue (VEGFA 抗体 (N-Term))

IHC

2 images

(105 references)

产品编号 ABIN3044494

发货至: 中国

Datasheet as PDF

抗原 See all VEGFA 抗体

VEGFA (Vascular Endothelial Growth Factor A (VEGFA))
抗原表位
17

15

15

14

12

7

6

6

5

4

4

3

3

3

3

3

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 33-48, N-Term
适用
142

94

69

18

17

16

13

7

5

3

3

2

1

1

1

1

1

1
人, 大鼠, 小鼠
宿主
166

54

9

2

1

1
兔
Compatible Secondaries
克隆类型
172

58

2
多克隆
标记
112

30

23

10

3

3

3

3

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1
This VEGFA antibody is un-conjugated
应用范围
165

87

47

39

39

26

23

20

18

15

11

10

10

8

3

3

2

2

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

原理

Anti-VEGF/VEGFA Antibody Picoband®

序列

VDIFQEYPDE IEYIFK

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

< a href="https://www.bosterbio.com/anti-vegf-antibody-a00045-boster.html" style="color:#EA8D28">Anti-VEGF/VEGFA Antibody (ABIN3044494). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the N-terminus of human VEGF, identical to the related mouse and rat sequences.

亚型

IgG

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anti-Vascular Endothelial Growth Factor A (VEGFA) (AA 27-190) antibody
VEGFA 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Vascular Endothelial Growth Factor A (VEGFA) (AA 27-214) antibody
VEGFA 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C2 unconjugated

anti-Vascular Endothelial Growth Factor A (VEGFA) (AA 27-126) antibody
VEGFA 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Vascular Endothelial Growth Factor A (VEGFA) (AA 207-371) antibody
VEGFA 适用: 人 WB, ELISA, ICC 宿主: 小鼠 Monoclonal 6G5B5 unconjugated

anti-Vascular Endothelial Growth Factor A (VEGFA) (AA 27-191) antibody
VEGFA 适用: 人, 大鼠, 小鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Vascular Endothelial Growth Factor A (VEGFA) (AA 27-130) antibody
VEGFA 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 3F7 unconjugated

anti-Vascular Endothelial Growth Factor A (VEGFA) (AA 207-371) antibody
VEGFA 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 6G5A10 unconjugated

anti-Vascular Endothelial Growth Factor A (VEGFA) (AA 81-132) antibody
VEGFA 适用: 人, 大鼠, 小鼠, 绵羊 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Vascular Endothelial Growth Factor A (VEGFA) (AA 141-180) antibody
VEGFA 适用: 人, 大鼠, 小鼠, 小鸡 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
1. Lee, C. G., Link, H., Baluk, P., Homer, R. J., Chapoval, S., Bhandari, V., Kang, M. J., Cohn, L., Kim, Y. K., McDonald, D. M., Elias, J. A. : Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nature Med. 10: 1095-1103, 2004. 2. Gerber, H.-P., Malik, A. K., Solar, G. P., Sherman, D., Liang, X. H., Meng, G., Hong, K., Marsters, J. C., Ferrara, N. : VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature 417: 954-958, 2002. 3. Jin, K., Zhu, Y., Sun, Y., Mao, X. O., Xie, L., Greenberg, D. A. : Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc. Nat. Acad. Sci. 99: 11946-11950, 2002.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

有效期

12 months
Zhang, Chu, Liu, Coates, Shang, Li: "Deer thymosin beta 10 functions as a novel factor for angiogenesis and chondrogenesis during antler growth and regeneration." in: Stem cell research & therapy, Vol. 9, Issue 1, pp. 166, (2019) (PubMed).

Liu, Kuang, Wu, Jin, Sun: "A novel polysaccharide from Sargassum integerrimum induces apoptosis in A549 cells and prevents angiogensis in vitro and in vivo." in: Scientific reports, Vol. 6, pp. 26722, (2018) (PubMed).

Yan-Ping, Xiao-Qin, Xiao Ping, Ying Quan: "Effects of Chronic Exposure to Sodium Arsenite on Expressions of VEGF and VEGFR2 Proteins in the Epididymis of Rats." in: BioMed research international, Vol. 2017, pp. 2597256, (2018) (PubMed).

Qin, Ke, Zhou, Wang, Liang, Wang, Yang, Gao, Ye, Kumar, Wang: "Metastasis-Associated Protein 1 Deficiency Results in Compromised Pulmonary Alveolar Capillary Angiogenesis in Mice." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 23, pp. 3932-3941, (2018) (PubMed).

Fang, Li, Qiao, Guo, Miao: "Neuroprotective effect of total flavonoids from Ilex pubescens against focal cerebral ischemia/reperfusion injury in rats." in: Molecular medicine reports, Vol. 16, Issue 5, pp. 7439-7449, (2018) (PubMed).

Yang, Zhang, Li, Wen: "MALAT1 enhanced the proliferation of human osteoblasts treated with ultra‑high molecular weight polyethylene by targeting VEGF via miR‑22‑5p." in: International journal of molecular medicine, Vol. 41, Issue 3, pp. 1536-1546, (2018) (PubMed).

Luo, Zhu, Wang, Yu, Zhou: "MicroRNA-126 affects ovarian cancer cell differentiation and invasion by modulating expression of vascular endothelial growth factor." in: Oncology letters, Vol. 15, Issue 4, pp. 5803-5808, (2018) (PubMed).

Zhang, Zhang, Yu, Du, Liu, Liu, An, Wang, Song, Li, Cao: "Effects of interferon tau on endometrial epithelial cells in caprine in vitro." in: Gene expression patterns : GEP, Vol. 25-26, pp. 142-148, (2017) (PubMed).

Lu, Shi, Ma, Wang, Liu, Chuai, Song, Münsterberg, Cao, Yang: "Proper autophagy is indispensable for angiogenesis during chick embryo development." in: Cell cycle (Georgetown, Tex.), Vol. 15, Issue 13, pp. 1742-54, (2017) (PubMed).

Gao, Chen, Gao, Wang, Sun, Yang: "CD47 deficiency in tumor stroma promotes tumor progression by enhancing angiogenesis." in: Oncotarget, Vol. 8, Issue 14, pp. 22406-22413, (2017) (PubMed).

Zhang, Yin, Ding, Zhang, Gao: "Vitamin K2 Ameliorates Damage of Blood Vessels by Glucocorticoid: a Potential Mechanism for Its Protective Effects in Glucocorticoid-induced Osteonecrosis of the Femoral Head in a Rat Model." in: International journal of biological sciences, Vol. 12, Issue 7, pp. 776-85, (2017) (PubMed).

Wang, Jiang, Xue: "Recombinant human endostatin reduces hypertrophic scar formation in rabbit ear model through down-regulation of VEGF and TIMP-1." in: African health sciences, Vol. 16, Issue 2, pp. 542-53, (2017) (PubMed).

Wang, Cao, Liu, Du, Wang, Chen, Liu, Wu: "5-Aminolaevulinic Acid-Based Photodynamic Therapy Restrains Pathological Hyperplasia of Fibroblasts." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 23, pp. 46-56, (2017) (PubMed).

Huang, Duan, Qian, Fan, Lv, Zhang, Han, Wu, Guo, Hu, Du, Chen, Jin: "Corrigendum: IL-17 Promotes Angiogenic Factors IL-6, IL-8, and Vegf Production via Stat1 in Lung Adenocarcinoma." in: Scientific reports, Vol. 7, pp. 39566, (2017) (PubMed).

Li, Chen, Chen, Mo, Li, Xiao, Yu, Guo: "Circular RNA 0000096 affects cell growth and migration in gastric cancer." in: British journal of cancer, Vol. 116, Issue 5, pp. 626-633, (2017) (PubMed).

Zhang, Liu, Liu, Zhou, Song, Cao, An: "miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression." in: PLoS ONE, Vol. 12, Issue 7, pp. e0179783, (2017) (PubMed).

Dai, Jia, Wang, Yang, Jiang, Chu: "Epidermal growth factor receptor transactivation is involved in the induction of human hepatoma SMMC7721 cell proliferation by insufficient radiofrequency ablation." in: Oncology letters, Vol. 14, Issue 2, pp. 2463-2467, (2017) (PubMed).

Zhang, Li, Zheng, Lin, Zhang, Zhang: "Inhibition of angiogenesis by arsenic trioxide via TSP-1-TGF-β1-CTGF-VEGF functional module in rheumatoid arthritis." in: Oncotarget, Vol. 8, Issue 43, pp. 73529-73546, (2017) (PubMed).

Zhong, Huang, Su, Zhang, Xu, Gong, Chen, Zeng, Chen, Zhou: "Downregulation of miR-199a-5p promotes prostate adeno-carcinoma progression through loss of its inhibition of HIF-1α." in: Oncotarget, Vol. 8, Issue 48, pp. 83523-83538, (2017) (PubMed).

Ning, Zhang, Tian, Li, Liu, Li, Tang: "The Involvement of β-Catenin/COX-2/VEGF Axis in NMDA-Caused Retinopathy." in: Journal of ophthalmology, Vol. 2017, pp. 9760501, (2017) (PubMed).

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抗原

VEGFA (Vascular Endothelial Growth Factor A (VEGFA))

别名

VEGFA (VEGFA 产品)

背景

Synonyms: Vascular endothelial growth factor A,VEGF-A,Vascular permeability factor,VPF,VEGFA,VEGF,
Tissue Specificity: Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland. .
Background: VEGF, a homodimeric glycoprotein of relative molecular mass 45,000, is the only mitogen that specifically acts on endothelial cells. It may be a major regulator of tumor angiogenesis in vivo. Vascular endothelial growth factor is a mitogen primarily for vascular endothelial cells. It is, however, structurally related to platelet-derived growth factor. VEGF shares homology with the PDGF A chain and B chain, including conservation of all 8 cysteines found in PDGFA and PDGFB. VEGF gene contains 8 exons. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo.
Sequence Similarities: Belongs to the PDGF/VEGF growth factor family.

分子量

27 kDa

UniProt

P15692

途径

RTK signaling, Glycosaminoglycan Metabolic Process, Regulation of Cell Size, Tube Formation, Signaling Events mediated by VEGFR1 and VEGFR2, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals, VEGF Signaling