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TIMP1 抗体 (C-Term)

Name: TIMP1 抗体 (C-Term)
SKU: ABIN3044394
Availability: OutOfStock

TIMP1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

Anti-TIMP1 antibody, Western blotting Lane 1: Recombinant Human TIMP-1 Protein 10ng Lane 2: Recombinant Human TIMP-1 Protein 5ng Lane 3: Recombinant Human TIMP-1 Protein 2. (TIMP1 抗体 (C-Term))

Anti-TIMP1 antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue (TIMP1 抗体 (C-Term))

IHC

2 images

(22 references)

产品编号 ABIN3044394

发货至: 中国

Datasheet as PDF

抗原 See all TIMP1 抗体

TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))
抗原表位
18

16

15

15

9

6

5

4

3

3

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1
AA 189-207, C-Term
适用
132

73

66

24

7

5

5

5

3

2

1

1

1
人
宿主
123

52

6

1

1
兔
Compatible Secondaries
克隆类型
125

57
多克隆
标记
86

25

17

8

4

4

3

3

3

3

3

3

3

3

3

3

3

2

2

2
This TIMP1 antibody is un-conjugated
应用范围
138

71

57

39

26

23

22

22

19

15

10

9

7

6

4

4

4

4

3

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

原理

Rabbit IgG polyclonal antibody for Metalloproteinase inhibitor 1(TIMP1) detection. Tested with WB, IHC-P in Human.

序列

CLPREPGLCT WQSLRSQIA

交叉反应（详细）

No cross reactivity with other proteins.

产品特性

Rabbit IgG polyclonal antibody for Metalloproteinase inhibitor 1(TIMP1) detection. Tested with WB, IHC-P in Human.
Gene Name: TIMP metallopeptidase inhibitor 1
Protein Name: Metalloproteinase inhibitor 1

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP-1(189-207aa CLPREPGLCTWQSLRSQIA).

亚型

IgG

Top Product

Discover our top product TIMP1 Primary Antibody
anti-TIMP Metallopeptidase Inhibitor 1 (TIMP1) (AA 103-207) antibody
TIMP1 适用: 人, 大鼠, 小鼠, 兔 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-TIMP Metallopeptidase Inhibitor 1 (TIMP1) (AA 157-188), (C-Term) antibody
TIMP1 适用: 人 WB, IHC (p), IF, FACS 宿主: 兔 Polyclonal RB14602 unconjugated

anti-TIMP Metallopeptidase Inhibitor 1 (TIMP1) (AA 41-70), (N-Term) antibody
TIMP1 适用: 人 WB, IHC (p), IF, FACS 宿主: 兔 Polyclonal RB15494 unconjugated

anti-TIMP Metallopeptidase Inhibitor 1 (TIMP1) (AA 25-207) antibody
TIMP1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-TIMP Metallopeptidase Inhibitor 1 (TIMP1) (AA 24-207) antibody
TIMP1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-TIMP Metallopeptidase Inhibitor 1 (TIMP1) antibody
TIMP1 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 8B4E9 unconjugated

anti-TIMP Metallopeptidase Inhibitor 1 (TIMP1) (AA 1-169) antibody
TIMP1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 4D12 unconjugated

anti-TIMP Metallopeptidase Inhibitor 1 (TIMP1) antibody
TIMP1 适用: 人, 猴 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2A5 unconjugated

anti-TIMP Metallopeptidase Inhibitor 1 (TIMP1) (AA 24-207) antibody
TIMP1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-TIMP Metallopeptidase Inhibitor 1 (TIMP1) (AA 131-207) antibody
TIMP1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

储存液

Thimerosal (Merthiolate), Sodium azide

注意事项

This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time.Avoid repeated freezing and thawing.

有效期

12 months
"Retraction: Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction." in: PLoS ONE, Vol. 13, Issue 2, pp. e0192465, (2018) (PubMed).

Wang, Jiang, Xue: "Recombinant human endostatin reduces hypertrophic scar formation in rabbit ear model through down-regulation of VEGF and TIMP-1." in: African health sciences, Vol. 16, Issue 2, pp. 542-53, (2017) (PubMed).

Li, Li, Zeng, Liu, Yang: "H2S improves renal fibrosis in STZ-induced diabetic rats by ameliorating TGF-β1 expression." in: Renal failure, Vol. 39, Issue 1, pp. 265-272, (2017) (PubMed).

Fan, Jiang, Li, Fang, Xu, Zheng: "MMP-1/2 and TIMP-1/2 expression levels, and the levels of collagenous and elastic fibers correlate with disease progression in a hamster model of tongue cancer." in: Oncology letters, Vol. 11, Issue 1, pp. 63-68, (2016) (PubMed).

Di, Nie, Chen: "Matrix metalloproteinase-9 and vascular endothelial growth factor expression change in experimental retinal neovascularization." in: International journal of ophthalmology, Vol. 9, Issue 6, pp. 804-8, (2016) (PubMed).

Jiang, Han, Li, Yang, Liu: "Carboxymethyl chitosan represses tumor angiogenesis in vitro and in vivo." in: Carbohydrate polymers, Vol. 129, pp. 1-8, (2015) (PubMed).

Song, Zou, Wang, Yang, Xie, Bi: "Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in early focal cerebral infarction following urokinase thrombolysis in rats." in: Neural regeneration research, Vol. 7, Issue 17, pp. 1325-30, (2015) (PubMed).

Deng, Ling, Liu, Zhao, Lv: "Decreased expression of matrix metalloproteinase-1 in the maternal umbilical serum, trophoblasts and decidua leads to preeclampsia." in: Experimental and therapeutic medicine, Vol. 9, Issue 3, pp. 992-998, (2015) (PubMed).

Yin, Li, Gao, Li, Li: "Andrographolide plays an important role in bleomycin-induced pulmonary fibrosis treatment." in: International journal of clinical and experimental medicine, Vol. 8, Issue 8, pp. 12374-81, (2015) (PubMed).

Xu, Dai, Liu, Liu, Song, Li, Chen, Lin: "Sanmiao formula inhibits chondrocyte apoptosis and cartilage matrix degradation in a rat model of osteoarthritis." in: Experimental and therapeutic medicine, Vol. 8, Issue 4, pp. 1065-1074, (2014) (PubMed).

Zhong, Wang, Jian: "Expression of matrix metalloproteinases-8 and -9 and their tissue inhibitor in the condyles of diabetic rats with mandibular advancement." in: Experimental and therapeutic medicine, Vol. 8, Issue 5, pp. 1357-1364, (2014) (PubMed).

Ma, Ma, Ma, Sun, Yu, Wang, Li, Ding: "The Effects of Uygur Herb Hyssopus officinalis L. on the Process of Airway Remodeling in Asthmatic Mice." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2014, pp. 710870, (2014) (PubMed).

Xu, Ling, Zhu, Fan, Zhang: "The effect of 2,3,4',5-tetrahydroxystilbene-2-0-?-D glucoside on neointima formation in a rat artery balloon injury model and its possible mechanisms." in: European journal of pharmacology, Vol. 698, Issue 1-3, pp. 370-8, (2013) (PubMed).

Jiang, Jin, Li, Zhang, Yang, Yang, Li, Yang, Ma: "Intermittent hypobaric hypoxia promotes atherosclerotic plaque instability in ApoE-deficient mice." in: High altitude medicine & biology, Vol. 14, Issue 2, pp. 175-80, (2013) (PubMed).

Hu, Wang, Zhao, Hu, Lu, Qin: "Overexpressed C-type natriuretic peptide serves as an early compensatory response to counteract extracellular matrix remodeling in unilateral ureteral obstruction rats." in: Molecular biology reports, Vol. 40, Issue 2, pp. 1429-41, (2013) (PubMed).

Jin, Jiang, Yang, Zhang, Yang, Zhang, Li, Yang, Ma: "Acipimox attenuates atherosclerosis and enhances plaque stability in ApoE-deficient mice fed a palmitate-rich diet." in: Biochemical and biophysical research communications, Vol. 428, Issue 1, pp. 86-92, (2012) (PubMed).

Zhao, Xue, Liu, Li, Wang, Li, Wang, Dong, Xue: "Differential effects of sulfated triterpene glycosides, holothurin A1, and 24-dehydroechinoside A, on antimetastasic activity via regulation of the MMP-9 signal pathway." in: Journal of food science, Vol. 75, Issue 9, pp. H280-8, (2011) (PubMed).

Wu, Zhang, Tang, Li, Chen, Zhang, Deng: "Effect of total saponins of "panax notoginseng root" on aortic intimal hyperplasia and the expressions of cell cycle protein and extracellular matrix in rats." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 17, Issue 3-4, pp. 233-40, (2010) (PubMed).

Liu, Ahmed, Nantajit, Rosenthal, Hai, Li: "Therapeutic effects of alpha-lipoic acid on bleomycin-induced pulmonary fibrosis in rats." in: International journal of molecular medicine, Vol. 19, Issue 6, pp. 865-73, (2007) (PubMed).

Xue, Zhang, Liu, Wang: "A new ATP-sensitive potassium channel opener protects the kidney from hypertensive damage in spontaneously hypertensive rats." in: The Journal of pharmacology and experimental therapeutics, Vol. 315, Issue 2, pp. 501-9, (2005) (PubMed).

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抗原

TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

别名

TIMP1 (TIMP1 产品)

别名

TIMP-1 antibody, TIMP1 antibody, DKFZp468A0912 antibody, CLGI antibody, EPA antibody, EPO antibody, HCI antibody, TIMP antibody, Timp antibody, Clgi antibody, TIMP metallopeptidase inhibitor 1 antibody, tissue inhibitor of metalloproteinase 1 antibody, TIMP1 antibody, Timp1 antibody

背景

TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms. This protein a member of the TIMP family. The glycoprotein is a natural inhibitor of the matrix metalloproteinases(MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. TIMP was found to be located about 22 cM proximal to OTC(300461).

Synonyms: Clgi antibody|Collagenase inhibitor antibody|EPA antibody|EPO antibody|Erythroid Potentiating Activity antibody|Erythroid-potentiating activity antibody|Fibroblast collagenase inhibitor antibody|FLJ90373 antibody|HCI antibody|Human Collagenase Inhibitor antibody|Metalloproteinase inhibitor 1 antibody|Metalloproteinase inhibitor 1 precursor antibody|OTTHUMP00000023214 antibody|TIMP 1 antibody|TIMP antibody|TIMP metallopeptidase inhibitor 1 antibody|TIMP-1 antibody|Timp1 antibody|TIMP1 protein antibody|TIMP1_HUMAN antibody|Tissue Inhibitor of Metalloproteinase 1 antibody|Tissue inhibitor of metalloproteinases 1 antibody|Tissue inhibitor of metalloproteinases antibody|Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor antibody

UniProt

P01033