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ERK1 抗体 (Middle Region)

MAPK3 适用: 人, 大鼠 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3044377
发货至: 中国
  • 抗原 See all ERK1 (MAPK3) 抗体
    ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))
    抗原表位
    • 80
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    AA 287-301, Middle Region
    适用
    • 252
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    • 45
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    • 7
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    人, 大鼠
    宿主
    • 262
    • 27
    • 4
    • 1
    • 1
    克隆类型
    • 238
    • 57
    多克隆
    标记
    • 119
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    This ERK1 antibody is un-conjugated
    应用范围
    • 247
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
    原理
    Rabbit IgG polyclonal antibody for Mitogen-activated protein kinase 3(MAPK3) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
    序列
    KTKVAWAKLF PKSDS
    交叉反应 (详细)
    Predicted Cross Reactivity: mouse
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    产品特性
    Rabbit IgG polyclonal antibody for Mitogen-activated protein kinase 3(MAPK3) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
    Gene Name: mitogen-activated protein kinase 3
    Protein Name: Mitogen-activated protein kinase 3(MAP kinase 3/MAPK 3)
    纯化方法
    Immunogen affinity purified.
    免疫原
    A synthetic peptide corresponding to a sequence in the middle region of human ERK1(287-301aa KTKVAWAKLFPKSDS), identical to the related mouse and rat sequences.
    亚型
    IgG
    Top Product
    Discover our top product MAPK3 Primary Antibody
  • 应用备注
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    储存液
    Thimerosal (Merthiolate), Sodium azide
    注意事项
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    有效期
    12 months
  • Han, Wu, Chang, Zhu, Xiao, Li, Zhang, Zhang: "Disulfiram inhibits TGF-β-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-κB/Snail pathway." in: Oncotarget, Vol. 6, Issue 38, pp. 40907-19, (2016) (PubMed).

    Tang, Zhang, Qi, Chen, Li, Liu, He, Li, Zu: "Afatinib inhibits proliferation and invasion and promotes apoptosis of the T24 bladder cancer cell line." in: Experimental and therapeutic medicine, Vol. 9, Issue 5, pp. 1851-1856, (2015) (PubMed).

    Liu, Zhu, Xiong, Zheng, Hu, Qiu: "Knockdown of protein tyrosine phosphatase receptor U inhibits growth and motility of gastric cancer cells." in: International journal of clinical and experimental pathology, Vol. 7, Issue 9, pp. 5750-61, (2014) (PubMed).

    Ma, Wang, Chen, Chen, Wang, Aisa: "Icariin and icaritin stimulate the proliferation of SKBr3 cells through the GPER1-mediated modulation of the EGFR-MAPK signaling pathway." in: International journal of molecular medicine, Vol. 33, Issue 6, pp. 1627-34, (2014) (PubMed).

    Yang, Han, Liu, Hu, Li, Zhu: "Negative pressure wound therapy is associated with up-regulation of bFGF and ERK1/2 in human diabetic foot wounds." in: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, Vol. 22, Issue 4, pp. 548-54, (2014) (PubMed).

    Li, Zhu, Liu, Liu, Wang, Xiong, Shen, Hu, Zheng: "ZFX knockdown inhibits growth and migration of non-small cell lung carcinoma cell line H1299." in: International journal of clinical and experimental pathology, Vol. 6, Issue 11, pp. 2460-7, (2013) (PubMed).

    Hu, Feng, Tang, Zhu, Lin, Yu: "LIF upregulates expression of NK-1R in NHBE cells." in: Mediators of inflammation, Vol. 2006, Issue 5, pp. 84829, (2007) (PubMed).

  • 抗原
    ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))
    别名
    MAPK3 (MAPK3 产品)
    别名
    ERK-1 antibody, ERK1 antibody, ERT2 antibody, HS44KDAP antibody, HUMKER1A antibody, P44ERK1 antibody, P44MAPK antibody, PRKM3 antibody, p44-ERK1 antibody, p44-MAPK antibody, Erk-1 antibody, Erk1 antibody, Ert2 antibody, Esrk1 antibody, Mnk1 antibody, Mtap2k antibody, Prkm3 antibody, p44 antibody, p44erk1 antibody, p44mapk antibody, ERK3 antibody, ERK6 antibody, P38GAMMA antibody, PRKM12 antibody, SAPK-3 antibody, SAPK3 antibody, fi06b09 antibody, wu:fi06b09 antibody, zERK1 antibody, Tb08.10J17.940 antibody, MAPK1 antibody, MNK1 antibody, AW123708 antibody, Erk6 antibody, P38gamma antibody, Prkm12 antibody, Sapk3 antibody, ATMAPK3 antibody, ATMPK3 antibody, T6D9.4 antibody, mitogen-activated protein kinase 3 antibody, mitogen-activated protein kinase 3 antibody, mitogen-activated protein kinase 12 antibody, mitogen activated protein kinase 3 antibody, mitogen-activated serine/threonine-protein kinase antibody, MAPK3 antibody, Mapk3 antibody, MAPK12 antibody, mapk3 antibody, Tc00.1047053509475.10 antibody, Tb927.8.3550 antibody, Mapk12 antibody, CEK1 antibody, MPK3 antibody
    背景
    Mitogen-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPK3 gene.The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases(ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. MAPK3 gene is mapped to human chromosome 16 by hybrid cell panel analysis.

    Synonyms: ERK 1 antibody|ERK antibody|ERK-1 antibody|ERK1 antibody|ERT 2 antibody|ERT2 antibody|Extracellular Signal Regulated Kinase 1 antibody|Extracellular signal related kinase 1 antibody|Extracellular signal-regulated kinase 1 antibody|HGNC6877 antibody|HS44KDAP antibody|HUMKER1A antibody|Insulin Stimulated MAP2 Kinase antibody|Insulin-stimulated MAP2 kinase antibody|MAP kinase 1 antibody|MAP kinase 3 antibody|MAP Kinase antibody|MAP kinase isoform p44 antibody|MAPK 1 antibody|MAPK 3 antibody|MAPK antibody|MAPK1 antibody|Mapk3 antibody|MGC20180 antibody|Microtubule Associated Protein 2 Kinase antibody|Microtubule-associated protein 2 kinase antibody|Mitogen Activated Protein Kinase 3 antibody|Mitogen-activated protein kinase 1 antibody|Mitogen-activated protein kinase 3 antibody|MK03_HUMAN antibody|OTTHUMP00000174538 antibody|OTTHUMP00000174541 antibody|p44 ERK1 antibody|p44 MAPK antibody|p44-ERK1 antibody|p44-MAPK antibody|P44ERK1 antibody|P44MAPK antibody|PRKM 3 antibody|PRKM3 antibody|Protein Kinase Mitogen Activated 3 antibody
    UniProt
    P27361
    途径
    MAPK Pathway, RTK signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, S100 Proteins
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