Neuregulin 1 抗体 (AA 2-241)
(1 reference)Quick Overview for Neuregulin 1 抗体 (AA 2-241) (ABIN3043580)
抗原
See all Neuregulin 1 (NRG1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2-241
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原理
- Anti-NRG1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-NRG1 Antibody Picoband® (ABIN3043580). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human NRG1 recombinant protein (Position: S2-K241). Human NRG1 shares 94% amino acid (aa) sequence identity with rat NRG1.
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亚型
- IgG
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anti-Neuregulin 1 (NRG1) (AA 617-636), (C-Term) antibody
NRG1 适用: 人, 大鼠, 小鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (C-Term) antibodyNRG1 适用: 人, 大鼠, 小鼠 WB, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (N-Term) antibodyNRG1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (AA 198-229) antibodyNRG1 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (AA 221-320) antibodyNRG1 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (AA 1-241) antibodyNRG1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (AA 21-242) antibodyNRG1 适用: 人 ELISA, IF, Coat 宿主: 小鼠 Monoclonal NRG1-2752 unconjugated
anti-Neuregulin 1 (NRG1) (AA 21-242) antibodyNRG1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal NRG1-2710 unconjugated
anti-Neuregulin 1 (NRG1) antibodyNRG1 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (Isoform 10) antibodyNRG1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
1. Fazzari, P., Paternain, A. V., Valiente, M., Pla, R., Lujan, R., Lloyd, K., Lerma, J., Marin, O., Rico, B.Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature 464: 1376-1380, 2010. 2. Go, R. C. P., Perry, R. T., Wiener, H., Bassett, S. S., Blacker, D., Devlin, B., Sweet, R. A. Neuregulin-1 polymorphism in late onset Alzheimer's disease families with psychoses. Am. J. Med. Genet. 139B: 28-32, 2005. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "Qiliqiangxin improves cardiac function and attenuates cardiac remodeling in rats with experimental myocardial infarction." in: International journal of clinical and experimental pathology, Vol. 8, Issue 6, pp. 6596-606, (2015) (PubMed).
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: "Qiliqiangxin improves cardiac function and attenuates cardiac remodeling in rats with experimental myocardial infarction." in: International journal of clinical and experimental pathology, Vol. 8, Issue 6, pp. 6596-606, (2015) (PubMed).
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- Neuregulin 1 (NRG1)
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别名
- NRG1
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背景
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Synonyms: Pro-neuregulin-1, membrane-bound isoform,Pro-NRG1,Neuregulin-1,Acetylcholine receptor-inducing activity,ARIA,Breast cancer cell differentiation factor p45,Glial growth factor,Heregulin,HRG,Neu differentiation factor,Sensory and motor neuron-derived factor,NRG1,GGF, HGL, HRGA, NDF, SMDF,
Tissue Specificity: Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells, in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific. .
Background: The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).
Sequence Similarities: Belongs to the neuregulin family.
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分子量
- 70 kDa
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基因ID
- 3084
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UniProt
- Q02297
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
抗原
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