LKB1 抗体 (AA 62-430)
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北京 101111
Quick Overview for LKB1 抗体 (AA 62-430) (ABIN3043300)
抗原
See all LKB1 (STK11) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 62-430
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原理
- Anti-LKB1/STK11 Antibody
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-LKB1/STK11 Antibody (ABIN3043300). Tested in WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human LKB1 recombinant protein (Position: K62-C430). Human LKB1 shares 89% amino acid (aa) sequence identity with both mouse and rat LKB1.
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亚型
- IgG
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anti-serine/threonine Kinase 11 (STK11) (AA 134-433) antibody
STK11 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (AA 14-44), (N-Term) antibodySTK11 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB3547 unconjugated
anti-serine/threonine Kinase 11 (STK11) (AA 14-44) antibodySTK11 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (pSer428) antibodySTK11 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (AA 19-48) antibodySTK11 适用: 人 WB, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (pThr189) antibodySTK11 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (Internal Region) antibodySTK11 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (AA 1-433) antibodySTK11 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (N-Term) antibodySTK11 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) antibodySTK11 适用: 人, 小鼠, 猴 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 4H12 unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
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说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "ART1 promotes starvation-induced autophagy: a possible protective role in the development of colon carcinoma." in: American journal of cancer research, Vol. 5, Issue 2, pp. 498-513, (2015) (PubMed).
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: "ART1 promotes starvation-induced autophagy: a possible protective role in the development of colon carcinoma." in: American journal of cancer research, Vol. 5, Issue 2, pp. 498-513, (2015) (PubMed).
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- LKB1 (STK11) (serine/threonine Kinase 11 (STK11))
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别名
- STK11
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背景
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Synonyms: Serine/threonine-protein kinase STK11,2.7.11.1,Liver kinase B1,LKB1,hLKB1,Renal carcinoma antigen NY-REN-19,STK11,LKB1, PJS,
Tissue Specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver.
Background: Serine/threonine kinase 11 or LKB1 is a protein kinase which in humans is encoded by the STK11 gene. The STK11 gene, which encodes a member of the serine/threonine kinase, regulates cell polarity and functions as a tumour suppressor. STK11 is a primary upstream kinase of adenine monophosphate-activated protein kinase (AMPK), a necessary element in cell metabolism that is required for maintaining energy homeostasis. It has been found that LKB1 physically associates with p53 and regulates specific p53-dependent apoptosis pathways. The STK11 gene extends over 23 kb of genomic DNA and is composed of 9 exons, which are transcribed in telomere-to-centromere ion.
Sequence Similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
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分子量
- 60 kDa
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基因ID
- 6794
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UniProt
- Q15831
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途径
- AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect
抗原
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