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IRS1 抗体 (AA 1041-1242)

IRS1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated

Western Blotting (WB) image for anti-Insulin Receptor Substrate 1 (IRS1) (AA 1041-1242) antibody (ABIN3043251) (IRS1 抗体 (AA 1041-1242))

Anti- IRS1 antibody, IHC(P) IHC(P): Mouse Intestine Tissue (IRS1 抗体 (AA 1041-1242))

Anti- IRS1 antibody, IHC(P) IHC(P): Rat Intestine Tissue (IRS1 抗体 (AA 1041-1242))

Anti- IRS1 antibody, IHC(P) IHC(P): Rat Skeletal Muscle Tissue (IRS1 抗体 (AA 1041-1242))

Anti- IRS1 antibody, IHC(P) IHC(P): Human Lung Cancer Tissue (IRS1 抗体 (AA 1041-1242))

Anti- IRS1 antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue (IRS1 抗体 (AA 1041-1242))

Anti- IRS1 antibody, Western blotting All lanes: Anti IRS1 at 0. (IRS1 抗体 (AA 1041-1242))

7 images

(1 reference)

产品编号 ABIN3043251

发货至: 中国

Datasheet as PDF

抗原 See all IRS1 抗体

IRS1 (Insulin Receptor Substrate 1 (IRS1))
抗原表位
30

26

26

22

22

18

17

16

16

16

16

5

4

4

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 1041-1242
适用
281

227

201

23

18

18

17

16

15

15

2

1

1
人, 小鼠, 大鼠
宿主
279

12
兔
Compatible Secondaries
克隆类型
273

18
多克隆
标记
108

13

10

10

10

10

10

10

10

10

10

10

10

10

9

6

6

6

6

6

6

4

1
This IRS1 antibody is un-conjugated
应用范围
141

123

99

87

74

54

51

38

24

17

14

7

3

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

原理

Anti-IRS1 Antibody Picoband®

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-IRS1 Antibody Picoband® (ABIN3043251). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human IRS1 recombinant protein (Position: S1041-Q1242). Human IRS1 shares 78% and 80% amino acid (aa) sequences identity with mouse and rat IRS1, respectively.

亚型

IgG

Top Product

Discover our top product IRS1 Primary Antibody
anti-Insulin Receptor Substrate 1 (IRS1) (pSer312) antibody
IRS1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor Substrate 1 (IRS1) (pSer636) antibody
IRS1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor Substrate 1 (IRS1) (pSer639) antibody
IRS1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor Substrate 1 (IRS1) (pSer307) antibody
IRS1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor Substrate 1 (IRS1) (AA 106-122), (N-Term) antibody
IRS1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor Substrate 1 (IRS1) (pSer636) antibody
IRS1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor Substrate 1 (IRS1) (Ser312) antibody
IRS1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor Substrate 1 (IRS1) (pSer1101) antibody
IRS1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor Substrate 1 (IRS1) (pTyr896) antibody
IRS1 适用: 人 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor Substrate 1 (IRS1) (pSer307) antibody
IRS1 适用: 人, 小鼠, 大鼠, 山羊 ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
1. Dearth RK, Cui X, Kim HJ, Kuiatse I, Lawrence NA, Zhang X, Divisova J, Britton OL, Mohsin S, Allred DC, Hadsell DL, Lee AV (December 2006)."Mammary Tumorigenesis and Metastasis Caused by Overexpression of Insulin Receptor Substrate 1 (IRS-1) or IRS-2". Molecular and Cellular Biology 26 (24): 9302-14. 2. Houghton, A. M., Rzymkiewicz, D. M., Ji, H., Gregory, A. D., Egea, E. E., Metz, H. E., Stolz, D. B., Land, S. R., Marconcini, L. A., Kliment, C. R., Jenkins, K. M., Beaulieu, K. A., Mouded, M., Frank, S. J., Wong, K. K., Shapiro, S. D. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nature Med. 16: 219-223, 2010. 3. Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., Goldstein, B. J., White, M. F. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352: 73-77, 1991.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Mi, Chen, Zheng, Li, Zhang, Mo, Yang: "MicroRNA-139-5p Suppresses 3T3-L1 Preadipocyte Differentiation Through Notch and IRS1/PI3K/Akt Insulin Signaling Pathways." in: Journal of cellular biochemistry, Vol. 116, Issue 7, pp. 1195-204, (2015) (PubMed).
抗原

IRS1 (Insulin Receptor Substrate 1 (IRS1))

别名

IRS1 (IRS1 产品)

背景

Synonyms: Insulin receptor substrate 1,IRS-1,IRS1,
Tissue Specificity: Lymphoid cells.
Background: Insulin receptor substrate 1 (IRS-1) is a signalling adapter protein that in humans is encoded by the IRS-1 gene. It is mapped to 2q36.3. This gene exhibited no intrinsic enzyme activity, and it can serve as a docking protein involved in binding and activating other signal transduction molecules after being phosphorylated on tyrosine by insulin receptor kinase. IRS1 plays a key role in transmitting signals from the insulin and insulin-like growth factor-1 (IGF-1) receptors to intracellular pathways PI3K/Akt and Erk MAP kinase pathways. IRS1 also has important biological function for both metabolic and mitogenic (growth promoting) pathways. In addition to those, IRS1 is a key regulator of PI3K within malignant cells.
Sequence Similarities: Contains 1 IRS-type PTB domain.

分子量

132 kDa

基因ID

3667

UniProt

P35568

途径

Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process

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