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CSNK1A1 抗体 (N-Term)

CSNK1A1 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3042767
发货至: 中国
  • 抗原 See all CSNK1A1 抗体
    CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))
    抗原表位
    • 27
    • 15
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    AA 30-68, N-Term
    适用
    • 107
    • 55
    • 46
    • 10
    • 8
    • 7
    • 7
    • 7
    • 5
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    人, 大鼠, 小鼠
    宿主
    • 102
    • 3
    • 2
    • 1
    克隆类型
    • 103
    • 6
    多克隆
    标记
    • 57
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    • 3
    • 3
    • 3
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    • 3
    • 3
    • 1
    • 1
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    This CSNK1A1 antibody is un-conjugated
    应用范围
    • 83
    • 49
    • 42
    • 21
    • 17
    • 14
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    • 13
    • 4
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    原理
    Rabbit IgG polyclonal antibody for Casein kinase I isoform alpha(CSNK1A1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    序列
    DIYLAINITN GEEVAVKLES QKARHPQLLY ESKLYKILQ
    交叉反应 (详细)
    No cross reactivity with other proteins.
    产品特性
    Rabbit IgG polyclonal antibody for Casein kinase I isoform alpha(CSNK1A1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: casein kinase 1, alpha 1
    Protein Name: Casein kinase I isoform alpha
    纯化方法
    Immunogen affinity purified.
    免疫原
    A synthetic peptide corresponding to a sequence at the N-terminus of human CSNK1A1 (30-68aa DIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQ), identical to the related mouse and rat sequences.
    亚型
    IgG
    Top Product
    Discover our top product CSNK1A1 Primary Antibody
  • 应用备注
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • 抗原
    CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))
    别名
    CSNK1A1 (CSNK1A1 产品)
    别名
    CK1 antibody, CK1a antibody, CKIa antibody, HLCDGP1 antibody, PRO2975 antibody, 2610208K14Rik antibody, 4632404G05Rik antibody, 5430427P18Rik antibody, Csnk1a antibody, CHUNP6894 antibody, ck1alpha antibody, wu:fb65a02 antibody, wu:fi30h04 antibody, wu:fj19c11 antibody, zgc:92158 antibody, KER1 antibody, ck1 antibody, CKIALPHA antibody, CK-II antibody, CSNK2A1 antibody, CG2028 antibody, CK I antibody, CK1alpha antibody, CKI antibody, CKI alpha antibody, CKIalpha antibody, CkIa antibody, Dmel\\CG2028 antibody, PKA-C antibody, anon-WO03040301.93 antibody, anon-WO03040301.95 antibody, ck1a antibody, dmCK1 antibody, dmckI antibody, l(1)G0492 antibody, casein kinase 1 alpha 1 antibody, casein kinase 1, alpha 1 antibody, keratin 1 antibody, casein kinase 1 alpha 1 L homeolog antibody, casein kinase 2 alpha 1 antibody, Casein kinase Ialpha antibody, CSNK1A1 antibody, Csnk1a1 antibody, csnk1a1 antibody, KRT1 antibody, csnk1a1.L antibody, CSNK2A1 antibody, CkIalpha antibody
    背景
    Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene. The CSNK1A1 gene is mapped to chromosome 5q32 based on an alignment of the CSNK1A1 sequence with the genomic sequence (GRCh37). It is reported that both screens identified CK1-alpha as a bifunctional regulator of NF-kappa-B. CK1-alpha dynamically associates with the CBM complex on T cell receptor engagement to participate in cytokine production and lymphocyte proliferation. However, CK1-alpha kinase activity has a contrasting role by subsequently promoting the phosphorylation and inactivation of CARMA1. CK1-alpha has thus a dual 'gating' function which first promotes and then terminates receptor-induced NF-kappa-B. ABC DLBCL cells required CK1-alpha for constitutive NF-kappa-B activity, indicating that CK1-alpha functions as a conditionally essential malignancy gene.

    Synonyms: Casein kinase 1 alpha 1 antibody|Casein kinase I isoform alpha antibody|CK1 antibody|CK1A antibody|CKI alpha antibody|CKI-alpha antibody|CKIa antibody|Clock regulator kinase antibody|Csnk1a1 antibody|Down regulated in lung cancer antibody|HLCDGP1 antibody| KC1A_HUMAN antibody|PRO2975 antibody
    基因ID
    1452
    UniProt
    P48729
    途径
    WNT signaling, Hedgehog Signaling
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