MAP2K4 抗体 (C-Term)
Quick Overview for MAP2K4 抗体 (C-Term) (ABIN3042559)
抗原
See all MAP2K4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 360-378, C-Term
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原理
- Anti-MEK4/MAP2K4 Antibody Picoband®
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序列
- ELLKHPFILM YEERAVEVA
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-MEK4/MAP2K4 Antibody (ABIN3042559). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human MEK4, different from the related mouse and rat sequences by one amino acid.
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亚型
- IgG
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anti-Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) antibody
MAP2K4 适用: 人 WB, IHC, IF, IHC (p), IP, FACS 宿主: 小鼠 Monoclonal 4B4 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) antibodyMAP2K4 适用: 人 WB, IHC, IF, IHC (p), IP 宿主: 小鼠 Monoclonal 1D6 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) antibodyMAP2K4 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2E4 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) (AA 137-394) antibodyMAP2K4 适用: 人 WB, ELISA, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) antibodyMAP2K4 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 5H4 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) (AA 1-399) antibodyMAP2K4 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) (AA 259-398) antibodyMAP2K4 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) (pSer80) antibodyMAP2K4 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) (pSer257), (pThr261) antibodyMAP2K4 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) (pThr261) antibodyMAP2K4 适用: 人 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
1. "Entrez Gene: MAP2K4 mitogen-activated protein kinase kinase 4" 2. Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M (May 1995). "Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2".Science 268 (5208): 286-90. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))
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别名
- MAP2K4
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背景
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Synonyms: Dual specificity mitogen-activated protein kinase kinase 4,MAP kinase kinase 4,MAPKK 4,2.7.12.2,JNK-activating kinase 1,MAPK/ERK kinase 4,MEK 4,SAPK/ERK kinase 1,SEK1,Stress-activated protein kinase kinase 1,SAPK kinase 1,SAPKK-1,SAPKK1,c-Jun N-terminal kinase kinase 1,JNKK,MAP2K4,JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1,
Tissue Specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
Background: Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4), also called SEK1 or JNKK1, is an enzyme that in humans is encoded by the MAP2K4 gene. It is mapped to 17p12. This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK1. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. MAP2K4 was a specific activator of JNK1, JNK2, and p38, and it has been shown to interact with FLNC, MAPK8, MAPK8IP3 and AKT1.
Sequence Similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
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分子量
- 44 kDa
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UniProt
- P45985
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途径
- MAPK Pathway, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling
抗原
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