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c-MET 抗体 (AA 208-407)

Name: c-MET 抗体 (AA 208-407)
SKU: ABIN3042360
Availability: OutOfStock

MET 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated

Observed bind size: 154KD (c-MET 抗体 (AA 208-407))

1 image

(3 references)

产品编号 ABIN3042360

发货至: 中国

Datasheet as PDF

抗原 See all c-MET (MET) 抗体

c-MET (MET) (Met Proto-Oncogene (MET))
抗原表位
49

35

28

21

16

12

11

8

7

7

7

6

5

5

4

4

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 208-407
适用
251

144

97

8

6

4

4

4

2

2

2

1

1

1

1
大鼠
宿主
221

39

3

2
兔
Compatible Secondaries
克隆类型
209

56
多克隆
标记
131

20

13

12

9

9

9

9

9

9

8

7

3

3

3

3

3

1

1

1

1

1
This c-MET antibody is un-conjugated
应用范围
181

105

51

43

31

27

26

24

15

8

8

7

4

4

1

1

1
Western Blotting (WB)

原理

Rabbit IgG polyclonal antibody for Hepatocyte growth factor receptor(MET) detection. Tested with WB in Human,Rat.

交叉反应（详细）

Predicted Cross Reactivity: human
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

产品特性

Rabbit IgG polyclonal antibody for Hepatocyte growth factor receptor(MET) detection. Tested with WB in Human,Rat.
Gene Name: MET proto-oncogene, receptor tyrosine kinase
Protein Name: Hepatocyte growth factor receptor

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human Met recombinant protein (Position: D208-S407). Human Met shares 90% and 91% amino acid (aa) sequences identity with mouse and rat Met, respectively.

亚型

IgG

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应用备注

WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Human, The detection limit for Met is approximately 0.25 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Chen, Ding, Gao, Sun, Zhang, Du, Qiu, Wang, Zheng, Sun, Ni, Feng, Zhu: "A human anti-c-Met Fab fragment conjugated with doxorubicin as targeted chemotherapy for hepatocellular carcinoma." in: PLoS ONE, Vol. 8, Issue 5, pp. e63093, (2013) (PubMed).

Bin, Ma, Xu, Shi: "Embryonic hepatocyte transplantation for hepatic cirrhosis: efficacy and mechanism of action." in: World journal of gastroenterology, Vol. 18, Issue 4, pp. 309-22, (2012) (PubMed).

Chen, Wang, Guo, Yu, Burnstock, He, Xiang, Zheng: "Expression of P2Y(6) receptors in the developing mouse skeletal muscle and after injury and repair." in: Journal of anatomy, Vol. 218, Issue 6, pp. 643-51, (2011) (PubMed).
抗原

c-MET (MET) (Met Proto-Oncogene (MET))

别名

MET (MET 产品)

别名

AUTS9 antibody, HGFR antibody, RCCP2 antibody, c-Met antibody, AI838057 antibody, HGF antibody, Par4 antibody, Hgfr antibody, c-met antibody, MET antibody, C-MET antibody, met antibody, met-A antibody, MET proto-oncogene, receptor tyrosine kinase antibody, met proto-oncogene antibody, MET proto-oncogene, receptor tyrosine kinase L homeolog antibody, MET antibody, Met antibody, met.L antibody

背景

C-Met, also called MET and hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. It is mapped to 7q31.2. The protein possesses tyrosine kinase activity. MET is a membrane receptor that is essential for embryonic development and wound healing. It induces several biological responses that collectively give rise to a program known as invasive growth. MET is deregulated in many types of human malignancies, including cancers of kidney, liver, stomach, breast, and brain. Normally, only stem cells and progenitor cells express MET, which allows these cells to grow invasively in order to generate new tissues in an embryo or regenerate damaged tissues in an adult. However, cancer stem cells are thought to hijack the ability of normal stem cells to express MET, and thus become the cause of cancer persistence and spread to other sites in the body.

Synonyms: AUTS9 antibody|c met antibody|c met antibody|cmet antibody|cmet antibody|D249 antibody|Hepatocyte growth factor receptor antibody|Hepatocyte growth factor receptor Precursor antibody|Hepatocyte growth factor receptor Precursor antibody|HGF antibody|HGF receptor antibody|HGF receptor antibody|HGF SF receptor antibody|HGF SF receptor antibody|HGF/SF receptor antibody|HGFR antibody|MET antibody|Met proto oncogene tyrosine kinase antibody|Met proto oncogene tyrosine kinase antibody|MET proto oncogene, receptor tyrosine kinase antibody|Met proto-oncogene (hepatocyte growth factor receptor) antibody|Met proto-oncogene antibody|Met protooncogene antibody|MET_HUMAN antibody|Oncogene MET antibody|Oncogene MET antibody|Par4 antibody|Proto-oncogene c-Met antibody|RCCP2 antibody|Renal cell carcinoma papillary 2 gene antibody|Renal cell carcinoma papillary 2 gene antibody|Scatter factor receptor antibody|SF receptor antibody|Tyrosine-protein kinase Met antibody

基因ID

4233

UniProt

P08581

途径

RTK signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor