IKAP/p150 抗体
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- 抗原 See all IKAP/p150 (ELP1) 抗体
- IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IKAP/p150 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- 特异性
- This antibody residues 148-161 IHQDDFGESKFITV of IKAP.
- 纯化方法
- Immunoaffinity Chromatography
- 免疫原
- Synthetic peptide
- 亚型
- IgG
- Top Product
- Discover our top product ELP1 Primary Antibody
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anti-Elongator Complex Protein 1 (ELP1) (AA 1107-1258) antibody
ELP1 适用: 人 WB, ELISA, IP, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Elongator Complex Protein 1 (ELP1) (AA 1242-1331) antibodyELP1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 6G9 unconjugated
anti-Elongator Complex Protein 1 (ELP1) (AA 1093-1332) antibodyELP1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Elongator Complex Protein 1 (ELP1) (C-Term) antibodyELP1 适用: 人, 小鼠 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Elongator Complex Protein 1 (ELP1) (C-Term) antibodyELP1 适用: 人, 小鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Immunohistochemistry on paraffin sections: 20 μg/mL. Western Blot: 1: 500 - 1: 1000. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.02 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- 抗原
- IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))
- 别名
- ELP1 / IKBKAP (ELP1 产品)
- 别名
- DYS antibody, ELP1 antibody, FD antibody, IKAP antibody, IKI3 antibody, TOT1 antibody, IKBKAP antibody, DKFZp469N1415 antibody, 3110040G09Rik antibody, 6030413P05 antibody, C78473 antibody, Elp1 antibody, Ikbkap antibody, elongator complex protein 1 antibody, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein antibody, ielongator complex protein 1 S homeolog antibody, inhibitor of kappa light polypeptide enhancer in B cells, kinase complex-associated protein antibody, ELP1 antibody, Elp1 antibody, IKBKAP antibody, elp1.S antibody, elp1 antibody, Ikbkap antibody
- 背景
- IKAP was initially identified as a scaffold protein of the IkappaB kinase complex that could bind to IKKa, IKKß, NF-kappaB, and the NF-kappaB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD). Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation. More recently, it was shown that IKAP associates with c-Jun N-terminal kinase (JNK) and could specifically enhance JNK activation induced by the upstream JNK activators MEKK1 and ASK1, indicating another possible cause for FD. At least two isoforms of IKAP are known two exist.Synonyms: Elongator complex protein 1, IKAP, IKK complex-associated protein, IkappaB kinase complex-associated protein, p150
- 基因ID
- 8518
- NCBI登录号
- NP_003631
- UniProt
- O95163
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