Cytochrome C 抗体
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Quick Overview for Cytochrome C 抗体 (ABIN3024589)
抗原
See all Cytochrome C (CYCS) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Protein G affinity chromatography
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免疫原
- Rat full-length protein was used as the immunogen for the Cytochrome C antibody.
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亚型
- IgG1 kappa
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anti-Cytochrome C, Somatic (CYCS) (AA 51-105) antibody
CYCS 适用: 人, 大鼠, 小鼠, 兔, 小鸡 WB, FACS, ELISA, IHC (p), ICC, IF (p), IHC (fro), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome C, Somatic (CYCS) (AA 1-105) antibodyCYCS 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome C, Somatic (CYCS) (AA 5-100) antibodyCYCS 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome C, Somatic (CYCS) (AA 13-99) antibodyCYCS 适用: 人, 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome C, Somatic (CYCS) (AA 5-100) antibodyCYCS 适用: 人 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Cytochrome C, Somatic (CYCS) antibodyCYCS 适用: 人, 大鼠, 小鼠, 小鸡 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
anti-Cytochrome C, Somatic (CYCS) (AA 1268-1341) antibodyCYCS 适用: 人, 大鼠, 小鼠 WB, IF, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome C, Somatic (CYCS) (AA 1-105) antibodyCYCS 适用: 人, 小鼠 WB, IHC, FACS, ELISA 宿主: 小鼠 Monoclonal 5E6B11 unconjugated
anti-Cytochrome C, Somatic (CYCS) (AA 2-105) antibodyCYCS 适用: 人, 大鼠, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome C, Somatic (CYCS) (AA 91-105), (C-Term) antibodyCYCS 适用: 人, 大鼠, 小鼠 WB, IHC, FACS, IF, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Cytochrome C antibody should be determined by the researcher.\. Western blot: 1-2 μg/mL, Immunoprecipitation: 2 μg/mg of lysate, Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the Cytochrome C antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- Cytochrome C (CYCS) (Cytochrome C, Somatic (CYCS))
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别名
- Cytochrome C
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背景
- Cytochrome c is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3.
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途径
- Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
抗原
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