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GPR37 抗体 (Extracellular Domain, N-Term)

GPR37 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN302333
发货至: 中国
  • 抗原 See all GPR37 抗体
    GPR37 (G Protein-Coupled Receptor 37 (Endothelin Receptor Type B-Like) (GPR37))
    抗原表位
    • 15
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain, N-Term
    适用
    • 47
    • 28
    • 15
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 46
    • 1
    克隆类型
    • 46
    • 1
    多克隆
    标记
    • 23
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
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    This GPR37 antibody is un-conjugated
    应用范围
    • 17
    • 15
    • 13
    • 13
    • 10
    • 5
    • 3
    • 2
    • 1
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    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    This antibody detects PAEL Receptor (GPR37).
    纯化方法
    Immunoaffinity Chromatography
    免疫原
    GPR37 antibody was raised against synthetic peptide from N-terminal extracellular domain of human GPR37.
    Top Product
    Discover our top product GPR37 Primary Antibody
  • 应用备注
    Immunohistochemistry on paraffin sections (3 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS containing 0.09 % sodium azide as preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.
  • 抗原
    GPR37 (G Protein-Coupled Receptor 37 (Endothelin Receptor Type B-Like) (GPR37))
    Abstract
    GPR37 产品
    别名
    ACCA antibody, EDNRBL antibody, PAELR antibody, hET(B)R-LP antibody, AI848630 antibody, Pael-R antibody, Ednrbl antibody, G protein-coupled receptor 3 antibody, G protein-coupled receptor 37 antibody, GPR3 antibody, GPR37 antibody, Gpr37 antibody
    背景
    GPR37 is an Orphan-A GPCR with an unknown ligand. GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinson's (PDJ) disease. The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when overexpressed, leading to unfolded protein-induced cell death. When the PAEL receptor is ubiquitinated by Parkin, it gets degraded, resulting in the suppression of cell death. The insoluble form of the PAEL receptor accumulates in the brains of PDJ patients and may cause selective neuronal death.Synonyms: ETBR-LP-1, Endothelin B receptor-like protein 1, G-protein coupled receptor 37, PAELR, Parkin-associated endothelin receptor-like receptor
    基因ID
    2861
    NCBI登录号
    NP_005293
    UniProt
    O15354
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