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TBP 抗体 (AA 1-100)

This anti-TBP antibody is a 兔 多克隆 antibody detecting TBP in WB. Suitable for 人.
产品编号 ABIN3023175
发货至: 中国

Quick Overview for TBP 抗体 (AA 1-100) (ABIN3023175)

抗原

See all TBP 抗体
TBP (TATA Box Binding Protein (TBP))

适用

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宿主

  • 63
  • 35
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克隆类型

  • 60
  • 40
多克隆

标记

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This TBP antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

    • 15
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    AA 1-100

    序列

    MTPGIPIFSP MMPYGTGLTP QPIQNTNSLS ILEEQQRQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQAVAAA AVQQSTSQQA TQGTSGQAPQ

    交叉反应

    产品特性

    Polyclonal Antibodies

    免疫原

    A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TBP (NP_001165556.1).

    亚型

    IgG
  • 应用备注

    WB,1:500 - 1:2000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid freeze / thaw cycles

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    TBP (TATA Box Binding Protein (TBP))

    别名

    TBP

    背景

    Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene.,TBP,GTF2D,GTF2D1,HDL4,SCA17,TFIID,Epigenetics & Nuclear Signaling,Transcription Factors,Nuclear Receptor Signaling,Neuroscience,Neurodegenerative Diseases,TBP

    分子量

    35 kDa/37 kDa

    基因ID

    6908

    UniProt

    P20226

    途径

    WNT signaling
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