GRB2 抗体 (AA 198-217)
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Quick Overview for GRB2 抗体 (AA 198-217) (ABIN302091)
抗原
See all GRB2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 198-217
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原理
- Anti-GRB2 Purified
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特异性
- The polyclonal antibody recognizes Grb2, a highly conserved approximately 26 kDa intracellular adaptor protein. The immunogen has 100 % identity between man, cow, rat and mouse.
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交叉反应 (详细)
- Human, Other species Not tested
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纯化方法
- Purified by ligand affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- Synthetic peptide corresponding to C-terminus of human Grb2 (amino acids 198-217).
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应用备注
- Western blotting: Recommended dilution: 1-2 μg/mL, reducing conditions.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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- GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))
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别名
- GRB2
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背景
- Growth factor receptor bound protein 2,Grb2 (growth factor receptor-bound protein 2) is a highly conserved adaptor protein composed of central SH2 domain flanked by two terminal SH3 domains. Grb2 mediates coupling of receptor protein tyrosine kinases to a guanine nucleotide exchange factor Sos, thereby enabling the tyrosine kinases to stimulate activity of Ras and hence of MAP kinase pathway. Grb2 also can bind to receptor protein tyrosine phosphatases and affect their signaling.,ASH, NCKAP2
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基因ID
- 2885
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UniProt
- P62993
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途径
- RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation
抗原
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