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CD68 抗体

CD68 适用: 人, 猴, Cow, Pig IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal PM-1K unconjugated
产品编号 ABIN290048
发货至: 中国
  • 抗原 See all CD68 抗体
    CD68 (CD68 Molecule (CD68))
    适用
    • 152
    • 76
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    人, 猴, Cow, Pig
    宿主
    • 88
    • 83
    • 11
    • 1
    小鼠
    克隆类型
    • 99
    • 80
    单克隆
    标记
    • 82
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    This CD68 antibody is un-conjugated
    应用范围
    • 75
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    • 21
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    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    纯化方法
    The splenic lymphocytes from BALB/c mouse, immunized with human peritoneal cells from patients with endometriosis incubated for 24 hours, were fused withmouse NS-1 myeloma cells. The hybridoma cell line with positive reaction was grown inascitic fluid of BALB/c mouse, from which the antibody was purified by Protein Gaffinity chromatography.
    免疫原
    human peritoneal cells from patients with endometriosis incubated for 24 hours
    克隆位点
    PM-1K
    亚型
    IgG2b kappa
    Top Product
    Discover our top product CD68 Primary Antibody
  • 应用备注
    Working dilution for immunohistochemistry: 10ug/ml, Please observe that this AB is not suitable for paraffin sample sections in tissues from all species (please inquire). Frozen sections are recommended.
    限制
    仅限研究用
  • 浓度
    0.25 mg/ml
    缓冲液
    PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)
    储存液
    ProClin
    储存条件
    -20 °C
  • 抗原
    CD68 (CD68 Molecule (CD68))
    别名
    Macrophage (CD68) (CD68 产品)
    别名
    Lamp4 antibody, Scard1 antibody, gp110 antibody, GP110 antibody, LAMP4 antibody, SCARD1 antibody, CD68 molecule antibody, CD68 antigen antibody, Cd68 molecule antibody, CD68 antibody, Cd68 antibody
    背景
    Macrophages are present in nearly all tissues and organs of the body. They are differentiated from monocytesderived from the bone marrow. Macrophages and monocytes are phagocytes, acting in both innate immunity andcell-mediated immunity of vertebrate animals. Their function is to phagocytize cellular debris and pathogens,and to stimulate lymphocytes and other immune cells to respond to the pathogen.Macrophages are able to be identified immnohistochemically by virtue of the presence ofmonocyte/macrophage-associated antigens such as CD68. Antibodies recognizing CD68 have been used as someof the best reagents to detect macrophages in tissues.CD68 is a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissuemacrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family.This antibody recognizes CD68 antigen. The molecular size of the antigen identified by this antibody was110 kDa. Immunopecipitated antigen by this antibody was also recognized by the other CD68 antibodies such asKP-1 and PG-M1.In immunohistochemical assays, this antibody recognizes freshly isolated human blood monocytes andtissue macrophages. This antibody also recognizes macrophages obtained from guinea pigs, pigs, bovine species,and monkeys. Since this antibody strongly labels guinea pig macrophages, this antibody will be suitable toexamine such macrophages in experimental guinea pig models.This antibody will be very useful to research of CD68, macrophage, allergic diseases and delayedhypersensitivity.
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