This mouse SG11 peptide sequence is 100 % conserved in rabbit, ovine, and sheep, 94 % in equine and rat, 89 % in pig, 84 % in human, 86 % in chicken SGLT-1. It also has high sequence homology with the low affinity SGLT- in mouse SGLT-4a/4b (84 % ), human SAAT1/SGLT-3 (78 % ), and SGLT-2 from human and rat (63 % ).
纯化方法
Affinity chromatography purified
免疫原
SGLT1 antibody was raised in rabbit using a 19 amino acid peptide sequence of mouse/rabbit SGLT-1 as the immunogen.
D22S675 antibody, NAGT antibody, SGLT1 antibody, zgc:66074 antibody, zgc:85782 antibody, SLC5A1 antibody, Sglt1 antibody, solute carrier family 5 member 1 antibody, solute carrier family 5 (sodium/glucose cotransporter), member 1 antibody, SLC5A1 antibody, slc5a1 antibody, Slc5a1 antibody
背景
Sodium glucose co transporters (SGLT), are active in the reabsorption of glucose in the proximal tubules of the kidneys. In the kidney, SGLT1 is expressed in proximal tubule Sq1 segments. SGLT1/NAGT or SLC5A1/NAGT (rat/mouse 665 aa, human 664 aa, chromosome 22q13.1, ~75 kDa) is a high affinity, Na+-coupled, intestinal transporter responsible for active glucose transport across the brush border membrane.