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NLRP3 抗体 (C-Term)

NLRP3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2856319
发货至: 中国
  • 抗原 See all NLRP3 抗体
    NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))
    抗原表位
    • 16
    • 8
    • 8
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 91
    • 57
    • 38
    • 23
    • 4
    • 2
    • 1
    • 1
    • 1
    宿主
    • 87
    • 11
    • 2
    • 1
    克隆类型
    • 85
    • 16
    多克隆
    标记
    • 44
    • 9
    • 8
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This NLRP3 antibody is un-conjugated
    应用范围
    • 63
    • 40
    • 22
    • 13
    • 13
    • 10
    • 10
    • 9
    • 7
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    交叉反应
    产品特性
    Rabbit polyclonal antibody to NLRP3 (NLR family, pyrin domain containing 3)
    Cryopyrin antibody [C3], C-term
    纯化方法
    Purified by antigen-affinity chromatography.
    免疫原
    Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human NLRP3. The exact sequence is proprietary.
    亚型
    IgG
    Top Product
    Discover our top product NLRP3 Primary Antibody
  • 应用备注
    WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    说明

    Validation: Orthogonal

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.7 mg/mL
    缓冲液
    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • 抗原
    NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))
    别名
    NLR family pyrin domain containing 3 (NLRP3 产品)
    别名
    CIAS1 antibody, Nalp3 antibody, avp antibody, cias1 antibody, nalp3 antibody, pypaf1 antibody, agtavprl antibody, AGTAVPRL antibody, AII antibody, AVP antibody, C1orf7 antibody, CLR1.1 antibody, FCAS antibody, FCU antibody, MWS antibody, NALP3 antibody, PYPAF1 antibody, AII/AVP antibody, Cias1 antibody, Mmig1 antibody, Pypaf1 antibody, NLR family pyrin domain containing-like antibody, NLR family pyrin domain containing 3 antibody, NLR family, pyrin domain containing 3 L homeolog antibody, NLR family, pyrin domain containing 3 antibody, NLRPL antibody, NLRP3 antibody, nlrp3.L antibody, Nlrp3 antibody
    背景
    This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data, however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

    Cellular Localization: Cytoplasm
    分子量
    118 kDa
    基因ID
    114548
    UniProt
    Q96P20
    途径
    Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome
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