ADAM17 抗体 (C-Term)
Quick Overview for ADAM17 抗体 (C-Term) (ABIN2855021)
抗原
See all ADAM17 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- C-Term
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
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Rabbit Polyclonal antibody to ADAM17 (ADAM metallopeptidase domain 17)
ADAM17 antibody [C2C3], C-term -
纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the C-terminus region of human ADAM17. The exact sequence is proprietary.
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亚型
- IgG
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应用备注
- WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: K562 , Raw264.7 , Rat2 , HeLa
Validation: KO/KD
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.21 mg/mL
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缓冲液
- 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
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别名
- ADAM metallopeptidase domain 17
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背景
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This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme, binds mitotic arrest deficient 2 protein, and also plays a prominent role in the activation of the Notch signaling pathway.
Cellular Localization: Membrane -
分子量
- 93 kDa
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基因ID
- 6868
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UniProt
- P78536
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途径
- Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus
抗原
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