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PCNA 抗体

Name: PCNA 抗体
Brand: antibodies-online
SKU: ABIN2854788
Availability: OutOfStock

Cited in 4+ publications. The 兔多克隆 anti-PCNA antibody (ABIN2854788) specifically detects PCNA in WB, IHC, IF, IP, IHC (p), ICC, IHC (fro) 和 FISH. The antibody is reactive with 人 samples.

WB Image PCNA antibody detects PCNA protein by western blot analysis. (PCNA 抗体)

The effects of ustekinumab and CUC on PCNA IE in IQ-induced psoriatic skin lesions. (PCNA 抗体)

ISt

IHC-P Image PCNA antibody detects PCNA protein at nucleus on mouse testis by immunohistochemical analysis. (PCNA 抗体)

IHC

IHC-P Image PCNA antibody detects PCNA protein at nucleus on rat hind brain by immunohistochemical analysis. (PCNA 抗体)

IHC

ICC/IF Image Confocal immunofluorescence analysis (Olympus FV10i) of methanol-fixed HeLa, using PCNA, antibody (Green) at 1:500 dilution. (PCNA 抗体)

ICC/IF Image PCNA antibody detects PCNA protein at nucleus by immunofluorescent analysis. (PCNA 抗体)

IHC-P Image PCNA antibody detects PCNA protein at nucleus in human cervical carcinoma by immunohistochemical analysis. (PCNA 抗体)

IHC

IP Image Immunoprecipitation of PCBP2 protein from HeLa whole cell extracts using 5 μg of PCBP2 antibody, Western blot analysis was performed using PCBP2 antibody, EasyBlot anti-Rabbit IgG was used as a secondary reagent. (PCNA 抗体)

IHC-P Image PCNA antibody detects PCNA protein at nucleus on mouse liver by immunohistochemical analysis. (PCNA 抗体)

IHC

IHC-P Image PCNA antibody detects PCNA protein at nucleus in human colon by immunohistochemical analysis. (PCNA 抗体)

IHC

Lycogen™ reduced cisplatin-induced cell apoptosis. (PCNA 抗体)

Combination of bortezomib and citreoviridin inhibited cell cycle progression through different cell cycle regulators. (PCNA 抗体)

Thyroid hormone induced proliferation in ovarian cancer cellsOVCAR-3 and SKOV-3 were treated with T3 (10-9 to 10-7 M) or T4 (10-8 to 10-6 M) for 3 days (A), 24 hours (B, upper panel) or 30 min (B, lower panel). (PCNA 抗体)

Changes in important mediators of inflammation and fibrosis in the obstructed kidney 7 days after UUO and the effects of Sirt1 activation or inhibition. (PCNA 抗体)

Prostate tumors grown from Cav1-silenced PC3 cells were accompanied by a more reactive tumor stroma. (PCNA 抗体)

IHC (p)

16 images

(4 references)

产品编号 ABIN2854788

发货至: 中国

Contact our Customer Service for availability and price in your country. Contact Info

Our Local Distributor

中国
北京 101111

No. 88 KeChuang 6th Street

Beijing Economic Technological Development Area

Room 801-803

4A Biotech Co.,Ltd.

Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for PCNA 抗体 (ABIN2854788)

抗原

See all PCNA 抗体

PCNA (Proliferating Cell Nuclear Antigen (PCNA))

适用

人

宿主

兔

克隆类型

多克隆

标记

This PCNA antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Fluorescence in situ hybridization (FISH)

Discover our top product PCNA Primary Antibody

特异性

IP/MS validation was supported by references (PMID:30377373)

交叉反应

Golden Syrian Hamster, 人, 小鼠, 大鼠

产品特性

Rabbit Polyclonal antibody to PCNA (proliferating cell nuclear antigen)
PCNA antibody

纯化方法

Purified by antigen-affinity chromatography.

免疫原

Recombinant protein encompassing a sequence within the center region of human PCNA. The exact sequence is proprietary.

亚型

IgG
anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 151-261) antibody
PCNA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 1-261) antibody
PCNA 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 1-261) antibody
PCNA 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 1G7 unconjugated

anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 1-261) antibody
PCNA 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal S1 unconjugated

anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 53-196) antibody
PCNA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 7H4F8 unconjugated

anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 53-196) antibody
PCNA 适用: 人, 猴 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 7H4F8 unconjugated

anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 201-261) antibody
PCNA 适用: 人, 小鼠, 大鼠, 小鸡 WB, ELISA, FACS, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 6-261) antibody
PCNA 适用: 人, 小鼠, 大鼠, Pig, 犬, 兔, 猕猴 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 231-261), (C-Term) antibody
PCNA 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB17486 unconjugated

anti-Proliferating Cell Nuclear Antigen (PCNA) (C-Term) antibody
PCNA 适用: 人, 小鼠, 大鼠, 犬, 斑马鱼, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

说明

Positive Control: NIH-3T3 , PC-12
Validation: IP/MS, Orthogonal

限制

仅限研究用
状态

Liquid

浓度

0.11 mg/mL

缓冲液

1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Mousa, Alhumaydhi, Abdellatif, Abdulmonem, AlKhowailed, Alsagaby, Al Rugaie, Alnuqaydan, Aljohani, Aljasir, Alwashmi, Soliman, Yosof, Elsheikh, Babiker, Alsuhaibani, Hegazy, Seleem: "Curcumin and ustekinumab cotherapy alleviates induced psoriasis in rats through their antioxidant, anti-inflammatory, and antiproliferative effects." in: Cutaneous and ocular toxicology, pp. 1-10, (2021) (PubMed).

Mousa, Soliman, Alhumaydhi, Almatroudi, Al Rugaie, Allemailem, Alrumaihi, Khan, Rezk, Aljasir, Alwashmi, Aba Alkhayl, Albutti, Seleem: "Garlic Extract Alleviates Trastuzumab-Induced Hepatotoxicity in Rats Through Its Antioxidant, Anti-Inflammatory, and Antihyperlipidemic Effects." in: Journal of inflammation research, Vol. 14, pp. 6305-6316, (2021) (PubMed).

Chen, Chen, Lin, Hsieh, Hsu, Hsieh: "Synergistic Anticancer Effects of Gemcitabine with Pitavastatin on Pancreatic Cancer Cell Line MIA PaCa-2 in vitro and in vivo." in: Cancer management and research, Vol. 12, pp. 4645-4665, (2020) (PubMed).

Hsieh, Wang, Changou, Chin, Yang, Lai, Lee, Yang, Whang-Peng, Liu, Lin, Mousa, Davis: "Crosstalk between integrin αvβ3 and ERα contributes to thyroid hormone-induced proliferation of ovarian cancer cells." in: Oncotarget, Vol. 8, Issue 15, pp. 24237-24249, (2018) (PubMed).
抗原

PCNA (Proliferating Cell Nuclear Antigen (PCNA))

别名

proliferating cell nuclear antigen

背景

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.

Cellular Localization: Nucleus

分子量

29 kDa

基因ID

5111

UniProt

P12004

途径

Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagy