PCNA 抗体
Quick Overview for PCNA 抗体 (ABIN2854788)
抗原
See all PCNA 抗体适用
宿主
克隆类型
标记
应用范围
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                                            特异性
- IP/MS validation was supported by references (PMID:30377373)
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                                            交叉反应
- Golden Syrian Hamster, 人, 小鼠, 大鼠
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                                            产品特性
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                        Rabbit Polyclonal antibody to PCNA (proliferating cell nuclear antigen)
 PCNA antibody
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                                            纯化方法
- Purified by antigen-affinity chromatography.
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                                            免疫原
- Recombinant protein encompassing a sequence within the center region of human PCNA. The exact sequence is proprietary.
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                                            亚型
- IgG
 
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                                            应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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                                            说明
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                        Positive Control: NIH-3T3 , PC-12 Validation: IP/MS, Orthogonal 
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                                            限制
- 仅限研究用
 
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                                            状态
- Liquid
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                                            浓度
- 0.11 mg/mL
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                                            缓冲液
- 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300
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                                            储存液
- ProClin
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                                            注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            储存条件
- 4 °C,-20 °C
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                                            储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
 
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                                            : "Curcumin and ustekinumab cotherapy alleviates induced psoriasis in rats through their antioxidant, anti-inflammatory, and antiproliferative effects."    in: Cutaneous and ocular toxicology, pp. 1-10, (2021)         (PubMed).        
 : "Garlic Extract Alleviates Trastuzumab-Induced Hepatotoxicity in Rats Through Its Antioxidant, Anti-Inflammatory, and Antihyperlipidemic Effects." in: Journal of inflammation research, Vol. 14, pp. 6305-6316, (2021) (PubMed).
 : "Synergistic Anticancer Effects of Gemcitabine with Pitavastatin on Pancreatic Cancer Cell Line MIA PaCa-2 in vitro and in vivo." in: Cancer management and research, Vol. 12, pp. 4645-4665, (2020) (PubMed).
 : "Crosstalk between integrin αvβ3 and ERα contributes to thyroid hormone-induced proliferation of ovarian cancer cells." in: Oncotarget, Vol. 8, Issue 15, pp. 24237-24249, (2018) (PubMed).
 
 
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                                            : "Curcumin and ustekinumab cotherapy alleviates induced psoriasis in rats through their antioxidant, anti-inflammatory, and antiproliferative effects."    in: Cutaneous and ocular toxicology, pp. 1-10, (2021)         (PubMed).        
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    - PCNA (Proliferating Cell Nuclear Antigen (PCNA))
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                                            别名
- proliferating cell nuclear antigen
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                                            背景
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                        The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. 
 Cellular Localization: Nucleus
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                                            分子量
- 29 kDa
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                                            基因ID
- 5111
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                                            UniProt
- P12004
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                                            途径
- Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagy
 抗原
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