PKN beta 抗体 (C-Term)
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- 抗原 See all PKN beta products
- PKN beta
- 抗原表位
- AA 463-492, C-Term
- 适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PKN beta antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 原理
- Rabbit Anti-Human PKN beta (C-term) Antibody
- 免疫原
- This PKN beta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 463-492 amino acids from the C-terminal region of human PKN beta.
- 亚型
- Ig Fraction
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anti-PKN beta (AA 463-492), (C-Term) antibody
适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB1043 unconjugated
anti-PKN beta antibody适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50Western blot analysis of anti-PKN-beta Pab , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry, clinical relevance has not been evaluated. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1.930 mg/mL
- 储存条件
- 4 °C,-20 °C
- 储存方法
- 2-8°C (short-term), -20°C (long-term)
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- 抗原
- PKN beta
- Abstract
- PKN beta 产品
- 背景
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Target Description: PKN3, a protein kinase C-related molecule, mediates malignant cell growth downstream of activated PI3K. PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 is regulated by PI3K at both the expression level and the catalytic activity level. Therefore, PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.
Gene Symbol: PKN3
- 分子量
- 99421 Da
- 基因ID
- 29941
- UniProt
- Q6P5Z2
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