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CDC42 抗体 (N-Term)

CDC42 适用: 犬, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2792111
发货至: 中国
  • 抗原 See all CDC42 抗体
    CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42))
    抗原表位
    • 16
    • 7
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    • 2
    • 1
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    • 1
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    N-Term
    适用
    • 81
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    • 11
    • 4
    • 4
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    • 2
    • 1
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    犬, 兔
    宿主
    • 75
    • 5
    • 2
    克隆类型
    • 65
    • 15
    多克隆
    标记
    • 36
    • 6
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    This CDC42 antibody is un-conjugated
    应用范围
    • 52
    • 27
    • 14
    • 13
    • 12
    • 11
    • 7
    • 7
    • 7
    • 6
    • 5
    • 3
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    Western Blotting (WB), Immunohistochemistry (IHC)
    序列
    DNYAVTVMIG GEPYTLGLFD TAGQEDYDRL RPLSYPQTDV FLVCFSVVSP
    预测反应
    Dog: 100%, Rabbit: 100%
    产品特性
    This is a rabbit polyclonal antibody against CDC42. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human CDC42
    Top Product
    Discover our top product CDC42 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 191 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42))
    别名
    CDC42 (CDC42 产品)
    别名
    CDC42Hs antibody, G25K antibody, AI747189 antibody, AU018915 antibody, cdc42a antibody, wu:fb07d08 antibody, wu:fj62g06 antibody, zgc:63918 antibody, Xcdc42 antibody, cdc42hs antibody, g25k antibody, CDC42 antibody, CG12530 antibody, Cdc42Dm antibody, D-CDC42 antibody, D-Cdc42 antibody, D-cdc42 antibody, DCDC42 antibody, DCdc42 antibody, Dcdc42 antibody, Dm Cdc42 antibody, DmCDC42 antibody, Dmcdc42 antibody, Dmel\\CG12530 antibody, cdc42 antibody, cell division cycle 42 antibody, Cell division control protein 42 homolog antibody, cell division control protein 42 homolog antibody, cell division cycle 42 L homeolog antibody, CG12530 gene product from transcript CG12530-RC antibody, Rho family GTPase antibody, CDC42 antibody, Cdc42 antibody, cdc42 antibody, LOC100636735 antibody, LOC100637699 antibody, LOC100638834 antibody, cdc42.L antibody
    背景
    CDC42 is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.
    Alias Symbols: CDC42Hs, G25K
    Protein Interaction Partner: PARD6B, CDC42EP1, CDC42EP2, PAK2, UBC, TRAF2, PAK1, ARHGDIA, BIRC2, TNK2, TCEB2, EPRS, LARS, RUVBL1, NEK6, WIPF1, WASL, RIOK3, SSX2IP, DIAPH3, BAIAP2, PAK3, ZNF420, IQGAP1, RAP1A, WAS, TGFBR2, TGFBR1, ARHGEF6, LRRK2, FGD3, ARHGAP1, SH3RF3, BCAR1, USP6, EL
    Protein Size: 191
    分子量
    21 kDa
    基因ID
    998
    NCBI登录号
    NM_001791, NP_001782
    UniProt
    P60953
    途径
    MAPK Pathway, Microtubule Dynamics, RTK signaling, WNT signaling, TCR Signaling, EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Signaling Events mediated by VEGFR1 and VEGFR2, EGFR Downregulation, VEGF Signaling
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