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IGF1R 抗体 (Middle Region)

This anti-IGF1R antibody is a 兔 多克隆 antibody detecting IGF1R in WB, IHC 和 IF. Suitable for 人, 小鼠, 大鼠, Cow, 斑马鱼, 犬, Pig, 马 和 绵羊. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN2792087
发货至: 中国

Quick Overview for IGF1R 抗体 (Middle Region) (ABIN2792087)

抗原

See all IGF1R 抗体
IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

适用

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人, 小鼠, 大鼠, Cow, 斑马鱼, 犬, Pig, 马, 绵羊

宿主

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克隆类型

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多克隆

标记

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This IGF1R antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
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    Middle Region

    序列

    DRHSGHKAEN GPGPGVLVLR ASFDERQPYA HMNGGRKNER ALPLPQSSTC

    特异性

    Directed to the beta chain of IGF1R

    预测反应

    Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rat: 92%, Sheep: 100%, Zebrafish: 100%

    产品特性

    This is a rabbit polyclonal antibody against IGF1R. It was validated on Western Blot using a cell lysate as a positive control.

    纯化方法

    Affinity Purified

    免疫原

    The immunogen is a synthetic peptide directed towards the middle region of human IGF1R
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator.

    说明

    Antigen size: 1367 AA

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Kubota, Elalieh, Saless, Fong, Wang, Babey, Cheng, Bikle: "Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading." in: Acta astronautica, Vol. 92, Issue 1, pp. 73-78, (2013) (PubMed).

  • 抗原

    IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

    别名

    IGF1R

    背景

    This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-140 DR007209.1 566-705 141-3559 X04434.1 136-3554 3560-4540 BC113610.1 3542-4522 4541-4921 DA486252.1 187-567 4922-5392 BX093045.1 248-718 5393-5768 CN414655.1 317-692 5769-6158 BM264223.1 185-574 6159-6580 BQ185364.1 187-608 6581-11242 AC069029.9 21278-25939 c
    Alias Symbols: CD221, IGFIR, JTK13, MGC142170, MGC142172, MGC18216, IGFR
    Protein Interaction Partner: KCNIP3, UBC, ESR1, PHB2, SHC1, FBXO6, SH2B1, Slc23a3, RPL11, HSP90AA1, GRB14, FFAR2, ARRB2, AMY2A, APP, RUVBL1, GNB2L1, ARRB1, YWHAG, TP53, NEDD4, MDM2, GRB10, SUMO1, CAMP, ERBB2, EGFR, KRT27, DOK5, DOK4, WISP2, EHD1, ARHGEF12, PIK3R3, VAV3, PRKD1, SOCS2,
    Protein Size: 1367

    分子量

    71 kDa

    基因ID

    3480

    NCBI登录号

    NM_000875, NP_000866

    UniProt

    P08069

    途径

    RTK signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy
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