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RRP8 抗体 (N-Term)

RRP8 适用: 人, 大鼠, Cow, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2791071
发货至: 中国
  • 抗原 See all RRP8 抗体
    RRP8 (Ribosomal RNA Processing 8 (RRP8))
    抗原表位
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 22
    • 10
    • 10
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    人, 大鼠, Cow, 马, 兔
    宿主
    • 20
    • 2
    克隆类型
    • 22
    多克隆
    标记
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RRP8 antibody is un-conjugated
    应用范围
    • 13
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB)
    序列
    GKKGKKKCQK QGPPCSDSEE EVERKKKCHK QALVGSDSAE DEKRKRKCQK
    预测反应
    Cow: 83%, Horse: 85%, Human: 100%, Rabbit: 85%, Rat: 93%
    产品特性
    This is a rabbit polyclonal antibody against RRP8. It was validated on Western Blot.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N-terminal region of Human RRP8
    Top Product
    Discover our top product RRP8 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 456 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    RRP8 (Ribosomal RNA Processing 8 (RRP8))
    别名
    RRP8 (RRP8 产品)
    别名
    KIAA0409 antibody, 1500003O22Rik antibody, 2900001K19Rik antibody, AW538116 antibody, RGD1308302 antibody, ribosomal RNA processing 8 antibody, ribosomal RNA processing 8, methyltransferase, homolog (yeast) antibody, RRP8 antibody, Rrp8 antibody
    背景
    RRP8 is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
    Alias Symbols: KIAA0409
    Protein Interaction Partner: RNF2, SIRT7, SIRT1, SUV39H1, USP39,
    Protein Size: 456
    分子量
    50 kDa
    基因ID
    23378
    NCBI登录号
    NM_015324, NP_056139
    UniProt
    O43159
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