PSME1 抗体 (Middle Region)
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- 抗原 See all PSME1 抗体
- PSME1 (Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28 Alpha) (PSME1))
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抗原表位
- Middle Region
- 适用
- 人, 小鼠, 大鼠, 犬, Pig, Cow, 兔, 豚鼠, Saccharomyces cerevisiae
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PSME1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- KEKEERKKQQ EKEDKDEKKK GEDEDKGPPC GPVNCNEKIV VLLQRLKPEI
- 预测反应
- Cow: 93%, Dog: 93%, Guinea Pig: 93%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 93%, Rat: 93%, Yeast: 83%
- 产品特性
- This is a rabbit polyclonal antibody against PSME1. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human PSME1
- Top Product
- Discover our top product PSME1 Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 250 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- PSME1 (Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28 Alpha) (PSME1))
- 别名
- PSME1 (PSME1 产品)
- 别名
- fk89d05 antibody, wu:fk89d05 antibody, IFI5111 antibody, PA28A antibody, PA28alpha antibody, REGalpha antibody, AW413925 antibody, PA28a antibody, proteasome activator subunit 1 antibody, proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) antibody, psme1 antibody, PSME1 antibody, Psme1 antibody
- 背景
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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified.The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified.
Alias Symbols: IFI5111, MGC8628, PA28A, PA28alpha, REGalpha
Protein Interaction Partner: HUWE1, PSME1, NAA10, PSMD14, SHFM1, UBC, PSME2, ADRM1, PSMA1, KIF5B, PARK2, BAG3, UBL7, PSRC1, PARVB, PHPT1, PRDX3, NUBP2, USP5, RBBP6, PSMD12, PSMD1, PSMC4, PSMC2, PSMB3, PSMB2, PSMB1, PSMA7, PSMA6, PSMA3, APP, OXCT1, CSE1L, GRB2, UBD, PSMD6, TUBG1, PSMB
Protein Size: 250 - 分子量
- 28 kDa
- 基因ID
- 5720
- NCBI登录号
- NM_176783, NP_788955
- UniProt
- Q06323
- 途径
- Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA
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