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- 抗原 See all PILRB 抗体
- PILRB (Paired Immunoglobin-Like Type 2 Receptor beta (PILRB))
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抗原表位
- Middle Region
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PILRB antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- KLTITQAVTT TTTWRPSSTT TIAGLRVTES KGHSESWHLS LDTAIRVALA
- 预测反应
- Human: 100%
- 产品特性
- This is a rabbit polyclonal antibody against PILRB. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human PILRB
- Top Product
- Discover our top product PILRB Primary Antibody
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anti-Paired Immunoglobin-Like Type 2 Receptor beta (PILRB) (AA 20-191) antibody
PILRB 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Paired Immunoglobin-Like Type 2 Receptor beta (PILRB) (AA 51-150) antibodyPILRB 适用: 人 ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Paired Immunoglobin-Like Type 2 Receptor beta (PILRB) antibodyPILRB 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Paired Immunoglobin-Like Type 2 Receptor beta (PILRB) (AA 146-195) antibodyPILRB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 227 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- PILRB (Paired Immunoglobin-Like Type 2 Receptor beta (PILRB))
- 别名
- PILRB (PILRB 产品)
- 别名
- FDFACT1 antibody, FDFACT2 antibody, FDFACT antibody, Fdact antibody, Pilrb antibody, paired immunoglobin-like type 2 receptor beta antibody, paired immunoglobin-like type 2 receptor beta 1 antibody, PILRB antibody, Pilrb1 antibody, Pilrb antibody
- 背景
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Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. Alternative splicing has been observed at this locus and three variants, encoding two distinct isoforms, are described. Additional transcript variants have been identified but their full-length nature has not been determined.
Alias Symbols: FDFACT1, FDFACT2
Protein Interaction Partner: BRCA1, ABHD16A, SAMSN1, PTPN6, PTPN11, LYN,
Protein Size: 227 - 分子量
- 23 kDa
- 基因ID
- 29990
- NCBI登录号
- NM_013440, NP_038468
- UniProt
- Q9UKJ0
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