This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer. Alias Symbols: EBP50, NHERF, NHERF-1, NHERF1, NPHLOP2 Protein Interaction Partner: ABCC4, UBC, MDM2, CKB, CAPN1, LDHAL6B, FTO, SMEK2, UBFD1, CNDP2, NANS, DAK, YWHAQ, GDA, NPEPPS, RPL23, YWHAZ, YWHAB, TGM2, SMS, RPS6KA3, LDHB, PDIA3, G6PD, ECHS1, CSE1L, CFTR, GNA11, PLCB1, EPHB1, PTEN, BCL10, ZNF468, gag-pol, MDH1, PALM2, PCYOX1, PPME1, Protein Size: 358