TRAF6 抗体 (Middle Region)
Quick Overview for TRAF6 抗体 (Middle Region) (ABIN2779305)
抗原
See all TRAF6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- YVTFMHLEAL RQRTFIKDDT LLVRCEVSTR FDMGSLRREG FQPRSTDAGV
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预测反应
- Cow: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against TRAF6. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human TRAF6
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anti-TNF Receptor-Associated Factor 6 (TRAF6) (AA 153-423) antibody
TRAF6 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 6 (TRAF6) (AA 413-522) antibodyTRAF6 适用: 人 WB, ELISA, RNAi, PLA 宿主: 小鼠 Monoclonal 1B2 unconjugated
anti-TNF Receptor-Associated Factor 6 (TRAF6) (AA 1-522) antibodyTRAF6 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 6 (TRAF6) (AA 263-522) antibodyTRAF6 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 6 (TRAF6) (AA 441-530) antibodyTRAF6 适用: 人, 小鼠, 大鼠, 小鸡 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 6 (TRAF6) (AA 314-343) antibodyTRAF6 适用: 人 WB 宿主: 兔 Polyclonal RB40708 unconjugated
anti-TNF Receptor-Associated Factor 6 (TRAF6) (AA 1-522) antibodyTRAF6 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 6 (TRAF6) (AA 1-522) antibodyTRAF6 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 6 (TRAF6) (C-Term) antibodyTRAF6 适用: 人, 小鼠 WB, IHC, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 6 (TRAF6) (AA 254-475) antibodyTRAF6 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 522 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))
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别名
- TRAF6
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背景
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TRAF6 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein.The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported.
Alias Symbols: MGC:3310, RNF85
Protein Interaction Partner: YES1, UBE2V1, UBE2N, UBE2L3, UBE2E1, UBE2D2, UBE2D1, POLI, UBC, IL1R1, EDARADD, PLEKHF2, LAT, TRAF3IP2, PPP4R1, USP2, IKBKG, TRAF6, TRAF5, TRAF2, TRAF1, CNTN2, SYK, VPS52, PSEN1, LGMN, MEOX2, MCL1, CANX, nef, TAB2, OTUD7A, GTF2I, KRAS, DCBLD2, MAP3K7, EIF
Protein Size: 522 -
分子量
- 59 kDa
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基因ID
- 7189
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NCBI登录号
- NM_004620, NP_004611
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UniProt
- Q9Y4K3
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途径
- NF-kappaB Signaling, TCR Signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Hepatitis C, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway
抗原
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