INSIG1 抗体 (Middle Region)
Quick Overview for INSIG1 抗体 (Middle Region) (ABIN2778635)
抗原
See all INSIG1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- TTWLFHKTRS NYRVFLKSPI VIESSKPPIL RARKILEENL TVDYDKDYLF
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预测反应
- Human: 100%, Mouse: 82%
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产品特性
- This is a rabbit polyclonal antibody against INSIG1. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human INSIG1
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anti-Insulin Induced Gene 1 (INSIG1) (AA 1-87) antibody
INSIG1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (Internal Region) antibodyINSIG1 适用: 人, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (AA 63-112) antibodyINSIG1 适用: 人, 小鼠, 大鼠, Cow, 山羊, 马, 兔, 犬, 豚鼠, Pig, 猴, Hamster, 非洲爪蟾, Bat, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (AA 36-63), (N-Term) antibodyINSIG1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21689 unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (Middle Region) antibodyINSIG1 适用: 人, 小鼠, 大鼠, Cow, 山羊, 马, 兔, 犬, 豚鼠, 绵羊, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (AA 71-120) antibodyINSIG1 适用: 人, 小鼠, 大鼠, Cow, 山羊, 马, 兔, 绵羊, Pig, Hamster, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (C-Term) antibodyINSIG1 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (C-Term) antibodyINSIG1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (Middle Region) antibodyINSIG1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (Middle Region) antibodyINSIG1 适用: 人, 小鼠, 大鼠, Cow, 山羊, 马, 兔, 犬, 豚鼠, 绵羊, Pig, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 330 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- INSIG1 (Insulin Induced Gene 1 (INSIG1))
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别名
- INSIG1
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背景
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Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. INSIG1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins.Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Alias Symbols: CL-6, MGC1405, CL6
Protein Interaction Partner: UBC, HMGCR, FAF2, SCAP, ERLIN2, ERLIN1, VCP, AMFR, PGRMC1, POR, SREBF1, ELAVL1, RNF139, INSIG2, PSMC3, PSMA7, INSIG1, VAPA, VAPB, SREBF2,
Protein Size: 330 -
分子量
- 36 kDa
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基因ID
- 3638
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NCBI登录号
- NM_198336, NP_938150
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UniProt
- A4D2M9
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途径
- ER-Nucleus Signaling
抗原
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