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INSIG1 抗体 (Middle Region)

INSIG1 适用: 人, 小鼠, 大鼠, Cow, 山羊, 马, 兔, 犬, 豚鼠, 绵羊, Pig, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2778638
发货至: 中国
  • 抗原 See all INSIG1 抗体
    INSIG1 (Insulin Induced Gene 1 (INSIG1))
    抗原表位
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Middle Region
    适用
    • 28
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, Cow, 山羊, 马, 兔, 犬, 豚鼠, 绵羊, Pig, 斑马鱼
    宿主
    • 28
    克隆类型
    • 28
    多克隆
    标记
    • 16
    • 4
    • 2
    • 2
    • 2
    • 2
    This INSIG1 antibody is un-conjugated
    应用范围
    • 24
    • 17
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB)
    序列
    WWVPPCCGTA SAVIGLLYPC IDRHLGEPHK FKREWSSVMR CVAVFVGINH
    预测反应
    Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 87%
    产品特性
    This is a rabbit polyclonal antibody against INSIG1. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the middle region of human INSIG1
    Top Product
    Discover our top product INSIG1 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 225 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    INSIG1 (Insulin Induced Gene 1 (INSIG1))
    别名
    INSIG1 (INSIG1 产品)
    别名
    cl-6 antibody, cl6 antibody, CL-6 antibody, CL6 antibody, fb55a03 antibody, fi35b10 antibody, wu:fb55a03 antibody, wu:fi35b10 antibody, zgc:55439 antibody, 1810013C12Rik antibody, Insig-1 antibody, INSIG-1 antibody, insulin induced gene 1 antibody, insulin induced gene 1 L homeolog antibody, INSIG1 antibody, insig1 antibody, insig1.L antibody, Insig1 antibody
    背景
    Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. INSIG1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins.The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: MGC26273, INSIG1
    Protein Interaction Partner: RNF5, HMGCR, SCAP, SREBF1, RNF139, UBQLN1, UBQLN2, FAF2, ADRM1, PSMD14, BAG6, VCP, UBC, RPN1, PSMD13, PSMD12, PSMD11, PSMD4, PSMC6, PSMC5, PSMC3, PSMC2, PSMB3, PSMB1, PSMA7, PSMA2, LGALS7, JUP, INSIG1, HSPA8, HSPA6, HSPA5, HSPA1A, ENO1, DSP, AMFR, SREBF2,
    Protein Size: 225
    分子量
    25 kDa
    基因ID
    51141
    NCBI登录号
    NM_016133, NP_057217
    UniProt
    Q9Y5U4
    途径
    ER-Nucleus Signaling
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