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GNAS 抗体 (N-Term)

Name: GNAS 抗体 (N-Term)
SKU: ABIN2776981
Availability: OutOfStock

GNAS 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated

WB Suggested Anti-GNAS Antibody Titration: 1. (GNAS 抗体 (N-Term))

Sample Type: Nthy-ori cell lysate (50ug)Primary Dilution: 1:1000Secondary Antibody: anti-rabbit HRPSecondary Dilution: 1:2000Image Submitted By: Anonymous (GNAS 抗体 (N-Term))

WB Suggested Anti-GNAS antibody Titration: 1 ug/mL Sample Type: Human MCF7 (GNAS 抗体 (N-Term))

4 images

产品编号 ABIN2776981

发货至: 中国

Datasheet as PDF

抗原 See all GNAS 抗体

GNAS (GNAS Complex Locus (GNAS))
抗原表位
16

10

8

8

7

6

5

3

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1
N-Term
适用
82

27

23

8

7

7

6

5

5

5

4

3

3

1

1

1

1

1

1

1
人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠
宿主
77

9

1
兔
Compatible Secondaries
克隆类型
79

8
多克隆
标记
47

9

8

7

5

5

1

1

1

1

1

1
This GNAS antibody is un-conjugated
应用范围
71

42

32

18

17

9

8

3

3

2

1

1
Western Blotting (WB)

序列

NPENQFRVDY ILSVMNVPDF DFPPEFYEHA KALWEDEGVR ACYERSNEYQ

预测反应

Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%

产品特性

This is a rabbit polyclonal antibody against GNAS. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Protein A purified

免疫原

The immunogen is a synthetic peptide directed towards the N terminal region of human GNAS

Top Product

Discover our top product GNAS Primary Antibody
anti-GNAS Complex Locus (GNAS) (AA 42-188) antibody
GNAS 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 2A2B7 unconjugated

anti-GNAS Complex Locus (GNAS) (N-Term) antibody
GNAS 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-GNAS Complex Locus (GNAS) antibody
KO Validated GNAS 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-GNAS Complex Locus (GNAS) (AA 42-188) antibody
GNAS 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 7G6G5 unconjugated

anti-GNAS Complex Locus (GNAS) (N-Term) antibody
GNAS 适用: 人, 小鼠, 大鼠, Cow, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-GNAS Complex Locus (GNAS) (AA 310-404) antibody
GNAS 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-GNAS Complex Locus (GNAS) (Internal Region) antibody
Verified GNAS 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-GNAS Complex Locus (GNAS) (AA 1-394) antibody
GNAS 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-GNAS Complex Locus (GNAS) (AA 287-315), (C-Term) antibody
GNAS 适用: 人 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal RB33001 unconjugated

anti-GNAS Complex Locus (GNAS) (AA 286-315), (C-Term) antibody
GNAS 适用: 人 WB, FACS, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 394 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
抗原

GNAS (GNAS Complex Locus (GNAS))

别名

GNAS (GNAS 产品)

别名

AHO antibody, C20orf45 antibody, GNAS1 antibody, GPSA antibody, GSA antibody, GSP antibody, NESP antibody, PHP1A antibody, PHP1B antibody, PHP1C antibody, POH antibody, GNAS antibody, PORGSA1 antibody, G-alpha-S antibody, 5530400H20Rik antibody, A930027G11Rik antibody, C130027O20Rik antibody, Galphas antibody, Gnas1 antibody, Gnasxl antibody, Gsa antibody, Nesp antibody, Nespl antibody, Oed-Sml antibody, Oedsml antibody, P1 antibody, P2 antibody, P3 antibody, G-alpha-s antibody, gnas-a antibody, Gnpas antibody, Nesp55 antibody, gnal antibody, Gnas antibody, GNAS complex locus antibody, guanine nucleotide-binding protein G(s) subunit alpha antibody, GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus antibody, GNAS complex locus S homeolog antibody, neuroendocrine secretory protein 55-like antibody, GNAS antibody, LOC694289 antibody, LOC469986 antibody, Gnas antibody, gnas.S antibody, gnas antibody, LOC100346323 antibody, LOC100442753 antibody, LOC100732436 antibody

背景

Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5' exons. Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes. However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual. In addition, one of the alternate 5' exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others. An antisense transcript exists, and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance. There are RefSeqs representing four transcript variants of this gene. Other transcript variants including four additional exons have been described, however, their full length sequences have not been determined.This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript exists, and this antisense transcript and one of the transcripts are paternally expressed, produce noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
Alias Symbols: AHO, C20orf45, GNAS1, GPSA, GSA, GSP, MGC33735, PHP1A, PHP1B, POH, dJ309F20.1.1, dJ806M20.3.3, NESP, PHP1C
Protein Interaction Partner: PANX1, AXIN1, UBC, FUS, OPTN, PTGIR, HLA-A, ADRB2, NUCB2, NUCB1, LAMTOR1, SLC25A12, GNAQ, GNA11, UBD, TBXA2R, GNB1, AVPR2, SUMO1, PCK1, Ric8b, GNG2, CALM1, Haus1, Trim69, Cbx1, RIC8A, TTC1, SNX13, ADCY5, CRHR1, PTGDR, TSHR, CAV3, HTR6, RGS2, ADCY6, VIPR1,
Protein Size: 394

分子量

46 kDa

基因ID

2778

NCBI登录号

NM_000516, NP_000507

UniProt

P63092

途径

Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Embryonic Body Morphogenesis