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- 抗原 See all Axin (AXIN1) 抗体
- Axin (AXIN1) (Axin 1 (AXIN1))
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抗原表位
- N-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Axin antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- TVGRDQALGA RQAERPWPPH SHPSTPEPSV RNDGKRRFMG VRRQGSRGAG
- 产品特性
- This is a rabbit polyclonal antibody against Axin1. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N-terminal region of Mouse Axin1
- Top Product
- Discover our top product AXIN1 Primary Antibody
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anti-Axin 1 (AXIN1) (AA 546-752) antibody
AXIN1 适用: 人 WB, ELISA, IHC, ICC, FACS, Neut 宿主: 小鼠 Monoclonal 4E9F1 unconjugated
anti-Axin 1 (AXIN1) (AA 618-827) antibodyAXIN1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Axin 1 (AXIN1) (AA 643-740) antibodyAXIN1 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2B11 unconjugated
anti-Axin 1 (AXIN1) (AA 470-570) antibody (Atto 488)AXIN1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal Atto 488
anti-Axin 1 (AXIN1) (AA 470-570) antibody (Atto 594)AXIN1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal Atto 594
anti-Axin 1 (AXIN1) (AA 470-570) antibody (Atto 390)AXIN1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal Atto 390
anti-Axin 1 (AXIN1) (AA 470-570) antibody (FITC)AXIN1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal FITC
anti-Axin 1 (AXIN1) (AA 470-570) antibody (Alkaline Phosphatase (AP))AXIN1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal Alkaline Phosphatase (AP)
anti-Axin 1 (AXIN1) (AA 470-570) antibody (APC)AXIN1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal APC
anti-Axin 1 (AXIN1) (AA 546-752) antibodyAXIN1 适用: 人 WB, ELISA, IHC, ICC, FACS, Neut 宿主: 小鼠 Monoclonal 4F10G1 unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 993 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- Axin (AXIN1) (Axin 1 (AXIN1))
- 别名
- Axin1 (AXIN1 产品)
- 别名
- AXIN1 antibody, axin antibody, fused antibody, xAxin antibody, LOC100226467 antibody, AXIN antibody, PPP1R49 antibody, AI316800 antibody, Axin antibody, Fu antibody, Kb antibody, Ki antibody, kinky antibody, knobbly antibody, AXIN1-RGS antibody, wu:fi22e03 antibody, wu:fj14c08 antibody, wu:fk11b03 antibody, zgc:109872 antibody, axin 1 antibody, axin 1 S homeolog antibody, axin 1 L homeolog antibody, AXIN1 antibody, axin1.S antibody, axin1.L antibody, Axin1 antibody, axin1 antibody
- 背景
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Axin1 is a component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Axin1 controls dorsoventral patterning via two opposing effects, down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. It also facilitates the phosphorylation of APC by GSK3B, facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation and enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7.
Alias Symbols: AI316800, Axin, Fu, Kb, Ki, fused, kinky, knobbly
Protein Interaction Partner: Lrp5, Gsk3b, Prmt1, Ctnnb1, GSK3A, Trp53, Hipk2, Nck2, Lrrk2, ITCH, WWP1, MAP3K1, Kif3a, Cops2, Dvl2, Axin1, Apc, Dixdc1, Ppp2r1a, Map3k4, Ppp2ca, Rnf111, Rnf11, Smad7, Smad6, Smad3, Dvl1, Cdh2, APC2,
Protein Size: 993 - 分子量
- 110 kDa
- 基因ID
- 12005
- NCBI登录号
- XM_914907, XP_920000
- UniProt
- O70239
- 途径
- WNT signaling, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling
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