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CAMKK2 抗体 (N-Term)

CAMKK2 适用: 人, 小鼠, 大鼠, Pig, 豚鼠, Cow, 兔, 犬, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2774040
发货至: 中国
  • 抗原 See all CAMKK2 抗体
    CAMKK2 (Calcium/calmodulin-Dependent Protein Kinase Kinase 2, beta (CAMKK2))
    抗原表位
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    N-Term
    适用
    • 57
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    • 2
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    人, 小鼠, 大鼠, Pig, 豚鼠, Cow, 兔, 犬, 斑马鱼
    宿主
    • 59
    • 7
    克隆类型
    • 61
    • 5
    多克隆
    标记
    • 37
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    This CAMKK2 antibody is un-conjugated
    应用范围
    • 61
    • 25
    • 16
    • 14
    • 10
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
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    Western Blotting (WB)
    序列
    GGLAAGGSLD MNGRCICPSL PYSPVSSPQS SPRLPRRPTV ESHHVSITGM
    预测反应
    Cow: 93%, Dog: 93%, Guinea Pig: 86%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 93%, Rat: 86%, Zebrafish: 79%
    产品特性
    This is a rabbit polyclonal antibody against CAMKK2. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human CAMKK2
    Top Product
    Discover our top product CAMKK2 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 498 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    CAMKK2 (Calcium/calmodulin-Dependent Protein Kinase Kinase 2, beta (CAMKK2))
    别名
    CAMKK2 (CAMKK2 产品)
    别名
    CAMKK antibody, CAMKKB antibody, 6330570N16Rik antibody, AW061083 antibody, mKIAA0787 antibody, camk2b antibody, fj90d04 antibody, wu:fj90d04 antibody, si:dkey-174n20.2 antibody, CAMKK2 antibody, calcium/calmodulin dependent protein kinase kinase 2 antibody, calcium/calmodulin-dependent protein kinase kinase 2, beta antibody, calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 antibody, calcium/calmodulin dependent protein kinase II beta antibody, calcium/calmodulin-dependent protein kinase kinase 2 antibody, CAMKK2 antibody, Camkk2 antibody, camk2b1 antibody, CAMK2B antibody, camkk2 antibody
    背景
    CAMKK2 is a calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. CAMKK2 seems to be involved in hippocampal activation of CREB1.The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Seven transcript variants encoding six distinct isoforms have been identified for this gene. Additional splice variants have been described but their full-length nature has not been determined. The identified isoforms exhibit a distinct ability to undergo autophosphorylation and to phosphorylate the downstream kinases.
    Alias Symbols: CAMKK, CAMKKB, KIAA0787, MGC15254
    Protein Interaction Partner: HSP90AA1, APP, UBC, NEDD4, CEP63, ESYT2, FANCI, OBSL1, ATG4B, XPOT, GCN1L1, IQGAP2, SMC3, SLC25A11, SMC1A, PRKDC, PRKAG1, PRKAA2, IRAK1, FLNC, FLNA, MAPK14, CALM1, CAMK4, CAMK1, PRKACA, SGK1,
    Protein Size: 498
    分子量
    55 kDa
    基因ID
    10645
    NCBI登录号
    NM_153500, NP_705720
    UniProt
    Q96RR4
    途径
    AMPK Signaling
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