Fusion Glycoprotein F0 (AA 136-608) 抗体 (HRP)
适用: Canine Distemper Virus (CDV)
ELISA, WB
宿主: 兔
Polyclonal
HRP
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- 抗原
- Fusion Glycoprotein F0
- 抗原表位
- AA 136-608
- 适用
- Canine Distemper Virus (CDV)
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- HRP
- 应用范围
- ELISA, Western Blotting (WB)
- 纯化方法
- Caprylic Acid Ammonium Sulfate Precipitation
- 免疫原
- Recombinant Canine distemper virus Fusion glycoprotein F0 protein(136-608aa)
- 亚型
- IgG
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C/-80 °C
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- 抗原
- Fusion Glycoprotein F0
- 物质类
- Viral Protein
- 背景
- Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (F protein) probably interacts with H at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis.
- UniProt
- P12569
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