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PARP1 抗体 (AA 215-525)
PARP1
适用: 人, 小鼠
WB, IHC, IP, ICC
宿主: 兔
Polyclonal
unconjugated
PARP1抗体详情
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抗原
See all PARP1 抗体
PARP1
(Poly (ADP-Ribose) Polymerase 1 (PARP1))
抗原表位
All epitopes for PARP1 抗体
AA 215-525
适用
All reactivities for PARP1 抗体
人, 小鼠
宿主
All hosts for PARP1 抗体
兔
克隆类型
All clonalities for PARP1 抗体
多克隆
标记
All conjugates for PARP1 抗体
This PARP1 antibody is un-conjugated
应用范围
All applications for PARP1 抗体
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)
特异性
Recognizes mouse PARP-1.
交叉反应
人, 小鼠
交叉反应 (详细)
Cross-reacts weakly with human PARP-1.
免疫原
Recombinant mouse PARP-1 [ARTD1] (aa 215-525).
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Alternatives
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使用细节
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应用备注
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
贮存及处理
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状态
Liquid
浓度
Lot specific
缓冲液
Contains 0.1 % sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C,-20 °C
储存方法
Short Term Storage: +4°C Long Term Storage: -20°C Stable for at least 1 year after receipt when stored at -20°C.
有效期
12 months
PARP1目标详情
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抗原
PARP1
(Poly (ADP-Ribose) Polymerase 1 (PARP1))
别名
PARP-1 [ARTD1] (PARP1 产品 )
别名
ADPRT antibody, ADPRT 1 antibody, ADPRT1 antibody, ARTD1 antibody, PARP antibody, PARP-1 antibody, PPOL antibody, pADPRT-1 antibody, Adprt antibody, Parp-1 antibody, 5830444G22Rik antibody, AI893648 antibody, Adprp antibody, Adprt1 antibody, C80510 antibody, parp-1 antibody, sPARP-1 antibody, BEST:LD21673 antibody, CG17685 antibody, CG17696 antibody, CG17718 antibody, CG40411 antibody, D.PARP antibody, Dm.pARTa antibody, Dmel\\CG40411 antibody, LD21673.3prime antibody, PARP1 antibody, dPARP antibody, parp antibody, adprt1 antibody, padprt-1 antibody, ppol antibody, si:dkey-206f10.3 antibody, wu:fc60f12 antibody, zgc:110092 antibody, poly(ADP-ribose) polymerase 1 antibody, poly (ADP-ribose) polymerase 1 antibody, poly (ADP-ribose) polymerase family, member 1 antibody, Poly-(ADP-ribose) polymerase antibody, poly(ADP-ribose) polymerase 1 L homeolog antibody, PARP1 antibody, Parp1 antibody, Parp antibody, parp1.L antibody, parp1 antibody
背景
PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
UniProt
P11103
途径
Apoptosis , Caspase Cascade in Apoptosis , DNA Damage Repair , Production of Molecular Mediator of Immune Response , Maintenance of Protein Location
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