ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
The catenins, α, β and γ, are proteins which bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. α-catenin was initially described as an E-cadherin associated protein, and since has been shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. β-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. β-catenin has also been found in complexes with the tumor suppressor protein APC. γ-catenin, also known as plakoglobin, is a protein that binds with α-catenin and N-cadherin. It has been shown that the transmembrane phosphatase PTPμ associates with catenin/cadherin complexes and may regulate complex signaling.Synonyms: Cancer-associated retinopathy protein, Protein CAR, RCV1, RCVRN