Phospholipase C gamma 2 抗体
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Quick Overview for Phospholipase C gamma 2 抗体 (ABIN272070)
抗原
See all Phospholipase C gamma 2 (PLCG2) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of PLCG2 protein. (region surrounding asn1211)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity Chromatography using epitope-specific immunogen.
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anti-Phospholipase C gamma 2 (PLCG2) (AA 1-300) antibody
PLCG2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Phospholipase C gamma 2 (PLCG2) (AA 826-985) antibodyPLCG2 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 2D9E8 unconjugated
anti-Phospholipase C gamma 2 (PLCG2) (AA 1201-1258) antibodyPLCG2 适用: 人 WB, IHC, ELISA, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Phospholipase C gamma 2 (PLCG2) (AA 1-1265) antibodyPLCG2 适用: 人 WB, PLA 宿主: 小鼠 Polyclonal unconjugated
anti-Phospholipase C gamma 2 (PLCG2) (AA 1-1265) antibodyPLCG2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Phospholipase C gamma 2 (PLCG2) (AA 1-1265) antibodyPLCG2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Phospholipase C gamma 2 (PLCG2) (pTyr753) antibodyPLCG2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Phospholipase C gamma 2 (PLCG2) (pTyr753) antibodyPLCG2 适用: 人 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 3A8B6 unconjugated
anti-Phospholipase C gamma 2 (PLCG2) (AA 826-985) antibodyPLCG2 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 1E10C11 unconjugated
anti-Phospholipase C gamma 2 (PLCG2) (AA 930-1152) antibodyPLCG2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/5000-1/10000. Western blot 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2, 0.05 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Phospholipase C gamma 2 (PLCG2)
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别名
- PLCG2
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背景
- Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC β1, PLC β2, PLC β3, PLC β4, PLC γ1, PLC γ2, PLC δ1, PLC δ2 and PLC ε). PLC βs are the only PLC isforms that are regulated by G protein subunits and are activated by a heterotrimeric GTP-binding protein linked to various cell surface receptors. Two alternatively spliced forms (1181 and 1166 amino acids) of PLC β2 are generated in haematopoietic cells that differ in the carboxyl-terminal sequence implicated in interaction of PLC β enzymes with G αq. The Pleckstrin homology domain of PLC β2 is required for its targeting to the membrane and for substrate hydrolysis and its linker region exerts an inhibitory effect on basal PLC β2 activity. PLC β2 plays a major role in platelet activation and is mainly expressed in the periphery of the islet and acinar cells in rat pancreas.Synonyms: 1-phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma-2, PLC-IV, PLC-gamma-2, Phosphoinositide phospholipase C-gamma-2, Phospholipase C-IV, Phospholipase C-gamma-2
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分子量
- approx. 148 kDa
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基因ID
- 5336
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NCBI登录号
- NP_002652
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UniProt
- P16885
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途径
- RTK signaling, WNT signaling, Fc-epsilon Receptor Signaling Pathway, Inositol Metabolic Process, Myometrial Relaxation and Contraction, Toll-Like Receptors Cascades, VEGF Signaling, BCR Signaling
抗原
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