FAS 抗体
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北京 101111
Quick Overview for FAS 抗体 (ABIN2689464)
抗原
See all FAS 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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产品特性
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Reacts with a 45 kD type I membrane molecule also known as APO-1, or Fas antigen. CD95 belongs to the tumor necrosis factor receptor (TNF-R) family of proteins and is expressed on various cells, including activated T cells and B cells. The interaction of CD95, Fas antigen, with Fas ligand is one of the many mechanisms that lead to apoptosis or programmed cell death. The interaction of CD95 expressing target cells with Fas ligand on cytotoxic T cells induces an apoptotic signal leading to target cell death. It has been reported that apoptosis is the mechanism used by the immune system in clonal deletion of self-reactive T cells during embryological development. Jurkat cells treated for 6 hours with CD95 (EOS9.1) Jurkat cells treated for 6 hours with mouse IgM isotype control
BD Pharmingen™ Purified Mouse Anti-Human CD95 - Purified - Clone EOS9.1 - Isotype Mouse IgM, κ - Reactivity Hu - 0.1 mg -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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亚型
- IgM kappa
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Aqueous buffered solution containing no preservative.
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储存液
- Without preservative
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注意事项
- This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C.
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: "The role of APO-1-mediated apoptosis in the immune system." in: Immunological reviews, Vol. 142, pp. 175-91, (1995) (PubMed).
: "The Fas death factor." in: Science (New York, N.Y.), Vol. 267, Issue 5203, pp. 1449-56, (1995) (PubMed).
: "Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity." in: The Journal of experimental medicine, Vol. 177, Issue 1, pp. 195-200, (1993) (PubMed).
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- FAS (TNF Receptor Superfamily, Member 6 (FAS))
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别名
- CD95
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背景
- Synonyms: Fas/APO-1
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途径
- p53 Pathway, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
抗原
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