(10 references)-
- 抗原 See all CD103 (ITGAE) 抗体
- CD103 (ITGAE) (Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE))
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This CD103 antibody is conjugated to Biotin
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应用范围
- Flow Cytometry (FACS)
- 品牌
- BD Pharmingen™
- 产品特性
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The M290 antibody reacts with the α chain of αIELβ7 integrin. CD103 has a unique and fairly restricted tissue distribution. It is expressed on almost all intestinal intraepithelial lymphocytes (IEL), on dendritic epidermal T cells (DEC), on subpopulations of peripheral T cells, and on distinct subsets of fetal, neonatal, and adult thymocytes. E-cadherin is the epithelial-cell ligand for αIELβ7 integrin. The ordered expression of αIEL during thymocyte development (which occurs under the influence of the thymic epithelium), the high level of expression of αIEL on those peripheral T cells found in epithelial tissues (IEL and DEC), and the expression of CD103 on a subset of CD8+ lymphocytes responding to allogeneic epithelial cells suggest that αIELβ7 integrin may have a common role in the interactions of T lymphocytes with epithelia during T-cell maturation and effector functions. CD103 is thought to play a role in allograft rejection. The M290 antibody is reported to efficiently inhibit αIELβ7-mediated adhesion in in vitro assays.
BD Pharmingen™ Biotin Rat Anti-Mouse CD103 - Biotin - Clone M290 - Isotype Rat IgG2a, κ - Reactivity Ms - 0.1 mg - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Mouse mammary tumor cells
- 克隆位点
- M290
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product ITGAE Primary Antibody
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anti-Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) antibody
ITGAE 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal ITGAE-2063 unconjugated
anti-Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) antibodyITGAE 适用: 人 IHC, StM, ISt 宿主: 小鼠 Monoclonal ITGAE-2474 unconjugated
anti-Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) antibodyITGAE 适用: 人 IHC, WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) antibodyITGAE 适用: 人, Non-Human Primate FACS, WB, IP, IHC (fro) 宿主: 小鼠 Monoclonal Ber-ACT8 unconjugated
anti-Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) antibody (APC)ITGAE 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal Ber-ACT8 APC
anti-Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) (AA 671-917) antibodyITGAE 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) (AA 19-200) antibodyITGAE 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) antibodyITGAE 适用: 小鼠 FACS, IHC, IP, IHC (fro) 宿主: 仓鼠 Monoclonal 2E7 unconjugated
anti-Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) (AA 57-171) antibodyITGAE 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6B8 unconjugated
anti-Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) antibody (FITC)ITGAE 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal Ber-ACT8 FITC
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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: "CD103 expression is required for destruction of pancreatic islet allografts by CD8(+) T cells." in: The Journal of experimental medicine, Vol. 196, Issue 7, pp. 877-86, (2002) (PubMed).
: "The epithelial cell-specific integrin, CD103 (alpha E integrin), defines a novel subset of alloreactive CD8+ CTL." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 8, pp. 3748-56, (1997) (PubMed).
: "Identification of a binding site for integrin alphaEbeta7 in the N-terminal domain of E-cadherin." in: The Journal of biological chemistry, Vol. 271, Issue 48, pp. 30909-15, (1997) (PubMed).
: "Distribution of alpha 4 beta 7 and alpha E beta 7 integrins on thymocytes, intestinal epithelial lymphocytes and peripheral lymphocytes." in: European journal of immunology, Vol. 26, Issue 4, pp. 897-905, (1996) (PubMed).
: "Recognition of E-cadherin on epithelial cells by the mucosal T cell integrin alpha M290 beta 7 (alpha E beta 7)." in: European journal of immunology, Vol. 25, Issue 3, pp. 852-6, (1995) (PubMed).
: "Developmental expression of the alpha IEL beta 7 integrin on T cell receptor gamma delta and T cell receptor alpha beta T cells." in: European journal of immunology, Vol. 24, Issue 3, pp. 635-40, (1994) (PubMed).
: "The mucosal T cell integrin alpha M290 beta 7 recognizes a ligand on mucosal epithelial cell lines." in: European journal of immunology, Vol. 23, Issue 7, pp. 1630-5, (1993) (PubMed).
: "Expression and regulation of beta 7(beta p) integrins on mouse lymphocytes: relevance to the mucosal immune system." in: European journal of immunology, Vol. 21, Issue 10, pp. 2591-7, (1991) (PubMed).
: "A new surface antigen on intraepithelial lymphocytes in the intestine." in: European journal of immunology, Vol. 20, Issue 10, pp. 2201-7, (1990) (PubMed).
: "A unique surface antigen on intraepithelial lymphocytes in the mouse." in: Immunology letters, Vol. 18, Issue 2, pp. 149-54, (1988) (PubMed).
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: "CD103 expression is required for destruction of pancreatic islet allografts by CD8(+) T cells." in: The Journal of experimental medicine, Vol. 196, Issue 7, pp. 877-86, (2002) (PubMed).
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- 抗原
- CD103 (ITGAE) (Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE))
- 别名
- CD103 (ITGAE 产品)
- 别名
- A530055J10 antibody, CD103 antibody, aM290 antibody, alpha-E1 antibody, alpha-M290 antibody, HUMINAE antibody, integrin alpha E, epithelial-associated antibody, integrin subunit alpha E antibody, Itgae antibody, ITGAE antibody
- 背景
- Synonyms: Integrin αIEL chain
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