Lamin A/C 抗体 (C-Term, Mature)
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北京 101111
Quick Overview for Lamin A/C 抗体 (C-Term, Mature) (ABIN2668842)
抗原
See all Lamin A/C (LMNA) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- C-Term, Mature
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原理
- Lamin A, mature antibody (mAb) (Clone 4A4)
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纯化方法
- Protein G Chromatography
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免疫原
- This Lamin A, mature antibody was raised against a peptide within the C-terminus of mature human Lamin A.
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亚型
- IgG1
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anti-Lamin A/C (LMNA) (AA 403-572) antibody
LMNA 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Lamin A/C (LMNA) antibodyKO Validated LMNA 适用: 人 WB, IF, ICC, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lamin A/C (LMNA) (pSer392) antibodyLMNA 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lamin A/C (LMNA) antibodyLMNA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 4E7 unconjugated
anti-Lamin A/C (LMNA) antibodyLMNA 适用: 人 IHC, IF, ELISA, IP, FACS 宿主: 兔 Monoclonal 4H7 unconjugated Recombinant Antibody
anti-Lamin A/C (LMNA) (AA 481-646) antibodyLMNA 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Lamin A/C (LMNA) (AA 455-469) antibodyLMNA 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lamin A/C (LMNA) antibodyLMNA 适用: 人, 小鼠, 大鼠, Cow, 犬 WB, IHC, ICC, FACS, IHC (fro) 宿主: 小鼠 Monoclonal 133A2 unconjugated
anti-Lamin A/C (LMNA) (AA 1-664) antibodyLMNA 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Lamin A/C (LMNA) (C-Term) antibodyLMNA 适用: 人, 小鼠, 大鼠, Cow, Pig, 犬, 猴, 兔, 马, Hamster, 小鸡, 绵羊, 豚鼠, Avian, Cat, 驴, 山羊 WB, IF 宿主: 山羊 Polyclonal unconjugated
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应用备注
- WB*: 0.05 - 2 μg/mL *Note: Many chromatin-bound proteins are not soluble in a low salt nuclear extract and fractionate to the pellet. Therefore, we recommend a High Salt / Sonication Protocol when preparing nuclear extracts for Western blot.
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限制
- 仅限研究用
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浓度
- 1 μg/μL
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缓冲液
- Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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: "Monoclonal antibodies specific for disease-associated point-mutants: lamin A/C R453W and R482W." in: PLoS ONE, Vol. 5, Issue 5, pp. e10604, (2010) (PubMed).
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- Lamin A/C (LMNA)
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别名
- Lamin A
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背景
- Nuclear lamins are intermediate filament proteins that are the major structural component of the nuclear lamina on the inner surface of the nuclear envelope. Lamins A and Lamins C are splice variants of the Lamin A gene. Lamin A/C (CDCD1, LMN1, EMD2) expression is a hallmark of embryonic stem cell differentiation. In addition to adding structural integrity to the nucleus, lamins contribute to the makeup of the nuclear matrix. Lamins also help organize interphase chromatin through interactions with several chromatin proteins, including histones and Lap2, such that alteration in lamin organization results in disruption of DNA replication, transcription and RNA processing.
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分子量
- 74 kDa
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基因ID
- 4000
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NCBI登录号
- NP_733821
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途径
- Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
抗原
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