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Histone 3 抗体 (H3K36me2)

Name: Histone 3 抗体 (H3K36me2)
SKU: ABIN2668402
Availability: OutOfStock

There are 3+ publications for this product available. The 小鼠单克隆 anti-Histone 3 antibody is suitable to detect Histone 3 in samples from 人. It has been validated for WB, IF, ChIP 和 DB.

Western blot of Histone H3 dimethyl Lys36 antibody. (Histone 3 抗体 (H3K36me2))

Dot blot of Histone Histone H3 dimethyl Lys36 antibody. (Histone 3 抗体 (H3K36me2))

2 images

(3 references)

产品编号 ABIN2668402

发货至: 中国

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Quick Overview for Histone 3 抗体 (H3K36me2) (ABIN2668402)

抗原

See all Histone 3 (H3) 抗体

Histone 3 (H3) (Histone H3 (H3))

适用

1796
1168
1020
48
40
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36
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31
23
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9
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人

宿主

小鼠

克隆类型

单克隆

标记

This Histone 3 antibody is un-conjugated

应用范围

1449
621
519
424
371
355
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177
158
121
49
48
42
37
26
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2
2
1
1
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Western Blotting (WB), Immunofluorescence (IF), Chromatin Immunoprecipitation (ChIP), Dot Blot (DB)

克隆位点

MABI 0332

Discover our top product H3 Primary Antibody

抗原表位
68

59

54

54

52

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50

49

45

40

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36

32

32

32

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31

29

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10
H3K36me2

原理

Histone H3K36me2 antibody (mAb) (Clone MABI 0332)

纯化方法

Protein G Chromatography

免疫原

This Histone H3 dimethyl Lys36 antibody was raised against a peptide containing dimethyl Lys36 of human Histone H3.

亚型

IgG1
anti-Histone H3 (H3) (H3K4me) antibody
H3 适用: 人 WB, IF, ChIP, IP, ChIP-seq, CUT&RUN 宿主: 兔 Polyclonal unconjugated

anti-Histone H3 (H3) (3meLys4) antibody
H3 适用: 人, Saccharomyces cerevisiae WB, IF, ChIP, ICC, DB, ChIP-seq, CUT&Tag, CUT&RUN 宿主: 兔 Polyclonal unconjugated

anti-Histone H3 (H3) (H3K27ac) antibody
H3 适用: 人, Saccharomyces cerevisiae WB, IHC, IF, ChIP, ICC, DB, ChIP-seq, CUT&Tag 宿主: 兔 Polyclonal unconjugated

anti-Histone H3 (H3) (H3K9ac) antibody
H3 适用: 人, 小鼠 WB, IF, ChIP, ICC, DB, ChIP-seq, CUT&Tag 宿主: 兔 Polyclonal unconjugated

anti-Histone H3 (H3) (H3K36me3) antibody
H3 适用: 人, 小鼠 WB, IF, ChIP, DB, ChIP-seq 宿主: 小鼠 Monoclonal MABI 0333 unconjugated

anti-Histone H3 (H3) (AA 71-136) antibody
H3 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Histone H3 (H3) (H3K27me) antibody
H3 适用: 人 WB, IHC, IF, ChIP, IP, ChIP-seq 宿主: 兔 Polyclonal unconjugated

anti-Histone H3 (H3) (H3K4me3) antibody
H3 适用: 人, 小鼠, Saccharomyces cerevisiae WB, IHC, IF, ChIP, ICC, DB, ChIP-seq, CUT&Tag, CUT&RUN 宿主: 兔 Polyclonal unconjugated

anti-Histone H3 (H3) (H3R2me2) antibody
H3 适用: 人 WB, IF, ChIP, IP, ChIP-seq 宿主: 兔 Polyclonal unconjugated

anti-Histone H3 (H3) (H3K36me2) antibody
H3 适用: 人 WB, IHC, IF, ChIP, IP, ChIP-seq 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 0.5 - 2 μg/mL dilution DB: 0.5 - 2 μg/mL dilution

限制

仅限研究用
浓度

0.69 μg/μL

缓冲液

PBS pH 7.5 containing 30 % glycerol and 0.035 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

储存条件

-20 °C

储存方法

Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

有效期

24 months
Amendola, Zaghet, Ramalho, Vilstrup Johansen, Boxem, Salcini: "JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity." in: PLoS genetics, Vol. 13, Issue 2, pp. e1006632, (2017) (PubMed).

García-Carpizo, Sarmentero, Han, Graña, Ruiz-Llorente, Pisano, Serrano, Brooks, Campbell, Barrero: "NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation." in: Scientific reports, Vol. 6, pp. 32952, (2016) (PubMed).

Rechtsteiner, Ercan, Takasaki, Phippen, Egelhofer, Wang, Kimura, Lieb, Strome: "The histone H3K36 methyltransferase MES-4 acts epigenetically to transmit the memory of germline gene expression to progeny." in: PLoS genetics, Vol. 6, Issue 9, pp. e1001091, (2010) (PubMed).
抗原

Histone 3 (H3) (Histone H3 (H3))

别名

Histone H3

背景

Histone H3 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation, these modifications play a major role in regulating gene expression. The methylation of histones can occur on two different residues: arginine or lysine. Histone methylation can be associated with transcriptional activation or repression, depending on the methylated residue. Histone H3 is methylated at lysine 36 by the Set2 (yeast) and NSD1 (mammals) methyltransferases. Dimethylation of lysine 36 of histone H3 is involved with transcriptional elongation by RNA pol II holoenzyme and is a marker of transcribed genes.

分子量

17 kDa

基因ID

3020

NCBI登录号

NP_003522