1810061I13Rik antibody, CLEC2 antibody, CLEC2B antibody, PRO1384 antibody, QDED721 antibody, Clec-2 antibody, Clec2 antibody, CLEC1B antibody, RGD1563517 antibody, CLEC9A antibody, C-type lectin domain family 1 member B antibody, C-type lectin domain family 1, member b antibody, C-type lectin domain family 1, member B antibody, CLEC1B antibody, Clec1b antibody
物质类
Viral Protein
背景
CLEC-2, also known as CLEC1B and CLEC1B1, is C-type lectin-like receptor with a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM). CLEC-2 is highly expressed on resting platelets and megakaryocytes and at a lower levels on several hematopoietic cells including monocytes, macrophages, dendritic cells, and granulocytes. The first ligand that was identified for CLEC-2 was the snake venom toxin rhodocytin, podoplanin has also been identified as an endogenous ligand for CLEC-2. Exposure of platelets to rhodocytin leads tyrosine phosphorylation of the ITAM-like motif and Syk-dependent platelet activation. CLEC-2 also functions as an activation receptor on monoyctes and neutrophils to induce phagocytosis and proinflammatory cytokine production.