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- 抗原 See all CLEC10A 抗体
- CLEC10A (C-Type Lectin Domain Family 10, Member A (CLEC10A))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CLEC10A antibody is un-conjugated
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应用范围
- ELISA (Capture)
- 纯化方法
- The antibody was purified by affinity chromatography.
- 克隆位点
- H037G3
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product CLEC10A Primary Antibody
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anti-C-Type Lectin Domain Family 10, Member A (CLEC10A) (AA 71-239) antibody
CLEC10A 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 10, Member A (CLEC10A) (AA 158-316) antibodyCLEC10A 适用: 人 WB, FACS, ELISA, IHC, ICC, Neut 宿主: 小鼠 Monoclonal 2C5C6F10 unconjugated
anti-C-Type Lectin Domain Family 10, Member A (CLEC10A) (AA 69-273) antibodyCLEC10A 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 10, Member A (CLEC10A) (AA 1-316) antibodyCLEC10A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 10, Member A (CLEC10A) (AA 70-169) antibodyCLEC10A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D6 unconjugated
anti-C-Type Lectin Domain Family 10, Member A (CLEC10A) antibodyCLEC10A 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 10, Member A (CLEC10A) (AA 60-180) antibodyCLEC10A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 10, Member A (CLEC10A) (AA 1-30), (N-Term) antibodyCLEC10A 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB28211 unconjugated
anti-C-Type Lectin Domain Family 10, Member A (CLEC10A) (AA 1-30), (N-Term) antibodyCLEC10A 适用: 人 WB, FACS, EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- 抗原
- CLEC10A (C-Type Lectin Domain Family 10, Member A (CLEC10A))
- 别名
- CD301 (CLEC10A 产品)
- 别名
- CLEC10A antibody, CD301 antibody, CLECSF13 antibody, CLECSF14 antibody, HML antibody, HML2 antibody, MGL antibody, CD301a antibody, M-ASGP-BP-1 antibody, Mgl antibody, Mgl1 antibody, Mgll antibody, C-type lectin domain family 10 member A antibody, C-type lectin domain containing 10A antibody, C-type lectin domain family 10, member A antibody, LOC607405 antibody, CLEC10A antibody, Clec10a antibody
- 背景
- CD301, also known as CLEC10A, macrophage galactose/N-acetylgalactosamine (GalNAc) specific lectin (MGL), DCASGPR, and HML, is a 40 kD type II transmembrane glycoprotein, which belongs to the C-type lectin family. Human CD301 consists of a 39 amino acid (aa) cytoplasmic region, a 21 aa transmembrane segment, and a 256 aa extracellular domain (ECD) with one carbohydrate recognition domain (CRD) and a neck region. CD301 is expressed on immature myleloid dendritic cells and alternatively activated (tolerogenic) macrophages. The expression level is upregulated by immunosuppressant dexamethasone. Human CD301 has an exclusive specificity for rare terminal GalNAc structures, which are revealed on the tumor-associated mucin MUC1 and CD45 (RA, RB, and RC but not RO isoforms). This interaction inhibits effector T cell activation and induces their apoptosis. CD301 also binds the GP envelope glycoprotein on Marburg and Ebola viruses and enhances viral entry and infectivity.
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