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KLRA1 抗体 (PE)

KLRA1 适用: 小鼠 FACS, IHC 宿主: 大鼠 Monoclonal YE1-48-10-6 PE
产品编号 ABIN2663821
发货至: 中国
  • 抗原 See all KLRA1 抗体
    KLRA1 (Killer Cell Lectin-Like Receptor, Subfamily A, Member 1 (KLRA1))
    适用
    • 6
    • 4
    • 4
    小鼠
    宿主
    • 5
    • 1
    大鼠
    克隆类型
    • 5
    • 1
    单克隆
    标记
    • 6
    This KLRA1 antibody is conjugated to PE
    应用范围
    • 6
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (IHC)
    纯化方法
    The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
    克隆位点
    YE1-48-10-6
    亚型
    IgG2a kappa
    Top Product
    Discover our top product KLRA1 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.2 mg/mL
    缓冲液
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Protect from prolonged exposure to light. Do not freeze.
    储存条件
    4 °C
    储存方法
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原
    KLRA1 (Killer Cell Lectin-Like Receptor, Subfamily A, Member 1 (KLRA1))
    别名
    Ly-49A (KLRA1 产品)
    别名
    Klra2 antibody, Ly49i8 antibody, A1 antibody, Klra22 antibody, Ly49a antibody, Ly49o<129> antibody, Ly49v antibody, LY49 antibody, KLRA1 antibody, Ly49 antibody, killer cell lectin-like receptor, subfamily A, member 1 antibody, killer cell lectin-like receptor subfamily A, member 1 antibody, Klra1 antibody, KLRA1 antibody, LY49 antibody
    背景
    Ly-49A is a 44 kD member of the C-type lectin/Ly-49 family proteins. It is a type-II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Ly-49A is present on a subset of NK and NK-T cells. Ly-49A, like other members of this family, inhibits NK cell activation through the recognition and interaction of certain MHC class I haplotypes on potential target cells. The Ly-49A receptor recognizes H-2Dd and H-2Dk, triggering phosphorylation of the ITIM motif in the cytoplasmic domain and recruitment of SHP-1 and SHP-2. The YE1/48.10.6 antibody reacts with NK cells from all mouse strains tested and reverses the inhibition of NK cytotoxicity.
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