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C-Type Lectin Domain Family 1, Member B (CLEC1B) 抗体 (PE)

CLEC1B 适用: 小鼠 ICFC 宿主: 大鼠 Monoclonal 17D9-CLEC2 PE
产品编号 ABIN2662694
发货至: 中国
  • 抗原 See all C-Type Lectin Domain Family 1, Member B (CLEC1B) 抗体
    C-Type Lectin Domain Family 1, Member B (CLEC1B)
    适用
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    小鼠
    宿主
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    大鼠
    克隆类型
    • 29
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    单克隆
    标记
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    PE
    应用范围
    • 25
    • 17
    • 10
    • 4
    • 4
    • 4
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    Intracellular Flow Cytometry (ICFC)
    纯化方法
    The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
    克隆位点
    17D9-CLEC2
    亚型
    IgG2b kappa
    Top Product
    Discover our top product CLEC1B Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.2 mg/mL
    缓冲液
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Protect from prolonged exposure to light. Do not freeze.
    储存条件
    4 °C
    储存方法
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原
    C-Type Lectin Domain Family 1, Member B (CLEC1B)
    别名
    CLEC2 (CLEC1B 产品)
    别名
    1810061I13Rik antibody, CLEC2 antibody, CLEC2B antibody, PRO1384 antibody, QDED721 antibody, Clec-2 antibody, Clec2 antibody, CLEC1B antibody, RGD1563517 antibody, CLEC9A antibody, C-type lectin domain family 1 member B antibody, C-type lectin domain family 1, member b antibody, C-type lectin domain family 1, member B antibody, CLEC1B antibody, Clec1b antibody
    物质类
    Viral Protein
    背景
    CLEC-2, also known as CLEC1B and CLEC1B1, is C-type lectin-like receptor with a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM). CLEC-2 is highly expressed on resting platelets and megakaryocytes and at a lower levels on several hematopoietic cells including monocytes, macrophages, dendritic cells, and granulocytes. The first ligand that was identified for CLEC-2 was the snake venom toxin rhodocytin, podoplanin has also been identified as an endogenous ligand for CLEC-2. Exposure of platelets to rhodocytin leads tyrosine phosphorylation of the ITAM-like motif and Syk-dependent platelet activation. CLEC-2 also functions as an activation receptor on monoyctes and neutrophils to induce phagocytosis and proinflammatory cytokine production.
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