The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
1810061I13Rik antibody, CLEC2 antibody, CLEC2B antibody, PRO1384 antibody, QDED721 antibody, Clec-2 antibody, Clec2 antibody, CLEC1B antibody, RGD1563517 antibody, CLEC9A antibody, C-type lectin domain family 1 member B antibody, C-type lectin domain family 1, member b antibody, C-type lectin domain family 1, member B antibody, CLEC1B antibody, Clec1b antibody
物质类
Viral Protein
背景
CLEC-2, also known as CLEC1B and CLEC1B1, is C-type lectin-like receptor with a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM). CLEC-2 is highly expressed on resting platelets and megakaryocytes and at a lower levels on several hematopoietic cells including monocytes, macrophages, dendritic cells, and granulocytes. The first ligand that was identified for CLEC-2 was the snake venom toxin rhodocytin, podoplanin has also been identified as an endogenous ligand for CLEC-2. Exposure of platelets to rhodocytin leads tyrosine phosphorylation of the ITAM-like motif and Syk-dependent platelet activation. CLEC-2 also functions as an activation receptor on monoyctes and neutrophils to induce phagocytosis and proinflammatory cytokine production.