ATM 抗体 (phosphorylated) (PE)
Quick Overview for ATM 抗体 (phosphorylated) (PE) (ABIN2662388)
抗原
See all ATM 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- phosphorylated
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纯化方法
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
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亚型
- IgG1 kappa
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anti-Ataxia Telangiectasia Mutated (ATM) (AA 1974-1988), (pSer1981) antibody
ATM 适用: 人 WB, IHC, ELISA, IF, IP, FACS, FM 宿主: 小鼠 Monoclonal 10H11-E12 unconjugated
anti-Ataxia Telangiectasia Mutated (ATM) (AA 1974-1988), (pSer1981) antibodyATM 适用: 人 WB, IHC, ELISA, IF, IP, FACS, FM 宿主: 小鼠 Monoclonal 10H11-E12 unconjugated
anti-Ataxia Telangiectasia Mutated (ATM) (C-Term) antibodyATM 适用: 人, 小鼠 WB, IHC, ELISA, IF, IP, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ataxia Telangiectasia Mutated (ATM) (AA 2681-2750) antibodyATM 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (p), FACS, IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ataxia Telangiectasia Mutated (ATM) (AA 2484-2748) antibodyATM 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ataxia Telangiectasia Mutated (ATM) antibodyATM 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Monoclonal 4E11 unconjugated Recombinant Antibody
anti-Ataxia Telangiectasia Mutated (ATM) (AA 1974-1988), (pSer1981) antibodyATM 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 7C10D8 unconjugated
anti-Ataxia Telangiectasia Mutated (ATM) (AA 1974-1988), (pSer1981) antibody (HRP)ATM 适用: 人 WB, IHC, ELISA, FM 宿主: 小鼠 Monoclonal 10H11-E12 HRP
anti-Ataxia Telangiectasia Mutated (ATM) (AA 486-742) antibodyATM 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ataxia Telangiectasia Mutated (ATM) antibodyATM 适用: 人 IHC, ELISA, FACS 宿主: 兔 Monoclonal 3G11 unconjugated Recombinant Antibody
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.2 mg/mL
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缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from prolonged exposure to light. Do not freeze.
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储存条件
- 4 °C
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储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- ATM (Ataxia Telangiectasia Mutated (ATM))
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别名
- ATM
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背景
- Ataxia telangiectasia mutated kinase (ATM) is a serine/threonine kinase that regulates cell cycle checkpoints and DNA repair. ATM is held inactive in unirradiated cells as a dimer or higher-order multimer. Cellular irradiation induces rapid intermolecular autophosphorylation of serine 1981 that causes dimer dissociation and initiates cellular ATM kinase activity. ATM kinase regulates a number of proteins involved in cell cycle checkpoint control, apoptosis, and DNA repair, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. Mutations in the corresponding ATM gene result in ataxia telangiectasia (AT), an autosomal recessive disease characterized by uncoordinated muscle movement and neurodegeneration. Cells from AT patients display defective DNA damage-induced checkpoint activation, sensitivity to radiation, and a higher frequency of chromosome breakage.
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途径
- p53 Pathway, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
抗原
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