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CD51 抗体 (Biotin)

ITGAV 适用: 小鼠 IF, ICFC 宿主: 大鼠 Monoclonal RMV-7 Biotin
产品编号 ABIN2661109
发货至: 中国
  • 抗原 See all CD51 (ITGAV) 抗体
    CD51 (ITGAV) (Integrin alpha V (ITGAV))
    适用
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    小鼠
    宿主
    • 65
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    大鼠
    克隆类型
    • 57
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    单克隆
    标记
    • 51
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    This CD51 antibody is conjugated to Biotin
    应用范围
    • 48
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    Immunofluorescence (IF), Intracellular Flow Cytometry (ICFC)
    纯化方法
    The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
    克隆位点
    RMV-7
    亚型
    IgG1 kappa
    Top Product
    Discover our top product ITGAV Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    储存条件
    4 °C
    储存方法
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原
    CD51 (ITGAV) (Integrin alpha V (ITGAV))
    别名
    CD51 (ITGAV 产品)
    别名
    1110004F14Rik antibody, 2610028E01Rik antibody, CD51 antibody, D430040G12Rik antibody, MSK8 antibody, VNRA antibody, VTNR antibody, Cd51 antibody, integrin subunit alpha V antibody, integrin alpha V antibody, ITGAV antibody, Itgav antibody
    背景
    CD51 is a 140 kD protein, also known as αV integrin, vitronectin receptor, and integrin αV. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins β1, β3, β5 or β6, these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The αv integrin heterodimers have varied functions in development, stimulation/activation and homeostasis. The primary ligands for CD51 complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.
    途径
    Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Integrin Complex
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